An analysis of the epidemic of klebsiella pneumoniae carbapenemase-producing k. pneumoniae: Convergence of two evolutionary mechanisms creates the "perfect storm"

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dc.contributor.authorRojas, Laura J
dc.contributor.authorWeinstock, George M
dc.contributor.authorde la Cadena, Elsa
dc.contributor.authorDiaz, Lorena
dc.contributor.authorRios, Rafael
dc.contributor.authorHanson, Blake M
dc.contributor.authorBrown, Joseph S
dc.contributor.authorVats, Purva
dc.contributor.authorPhillips, Daniel S
dc.contributor.authorNguyen, Hoan
dc.contributor.authorHujer, Kristine M
dc.contributor.authorCorrea, Adriana
dc.contributor.authorAdams, Mark D
dc.contributor.authorPerez, Federico
dc.contributor.authorSodergren, Erica
dc.contributor.authorNarechania, Apurva
dc.contributor.authorPlanet, Paul J
dc.contributor.authorVillegas, María Virginia
dc.contributor.authorBonomo, Robert A
dc.contributor.authorArias, Cesar A.
dc.contributor.orcidde la Cadena, Elsa [0000-0003-0361-7893]
dc.contributor.orcidVillegas, María Virginia [0000-0003-1898-9067]
dc.date.accessioned2020-05-15T17:03:00Z
dc.date.available2020-05-15T17:03:00Z
dc.date.issued2018
dc.description.abstractenglishBackground Carbapenem resistance is a critical healthcare challenge worldwide. Particularly concerning is the widespread dissemination of Klebsiella pneumoniae carbapenemase (KPC). Klebsiella pneumoniae harboring blaKPC (KPC-Kpn) is endemic in many areas including the United States, where the epidemic was primarily mediated by the clonal dissemination of Kpn ST258. We postulated that the spread of blaKPC in other regions occurs by different and more complex mechanisms. To test this, we investigated the evolution and dynamics of spread of KPC-Kpn in Colombia, where KPC became rapidly endemic after emerging in 2005. Methods We sequenced the genomes of 133 clinical isolates recovered from 24 tertiary care hospitals located in 10 cities throughout Colombia, between 2002 (before the emergence of KPC-Kpn) and 2014. Phylogenetic reconstructions and evolutionary mapping were performed to determine temporal and genetic associations between the isolates. Results Our results indicate that the start of the epidemic was driven by horizontal dissemination of mobile genetic elements carrying blaKPC-2, followed by the introduction and subsequent spread of clonal group 258 (CG258) isolates containing blaKPC-3. Conclusions The combination of 2 evolutionary mechanisms of KPC-Kpn within a challenged health system of a developing country created the “perfect storm” for sustained endemicity of these multidrug-resistant organisms in Colombia.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jix524
dc.identifier.issn1537-6613
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2833
dc.language.isoeng
dc.publisherOxford University Pressspa
dc.publisher.journalJournal of Infectious Diseasesspa
dc.relation.ispartofseriesJournal of Infectious Diseases, 1537-6613, Vol 217, Num 1, 2018, pag 82–92spa
dc.relation.urihttps://academic.oup.com/jid/article/217/1/82/4259398
dc.rights.creativecommons2017
dc.rights.localAcceso cerradospa
dc.subject.decsEpidemiologíaspa
dc.subject.decsCarbapenemasaspa
dc.subject.keywordsColombiaspa
dc.subject.keywordsKlebsiella pneumoniaespa
dc.subject.keywordsKPCspa
dc.titleAn analysis of the epidemic of klebsiella pneumoniae carbapenemase-producing k. pneumoniae: Convergence of two evolutionary mechanisms creates the "perfect storm"spa
dc.title.translatedAn analysis of the epidemic of klebsiella pneumoniae carbapenemase-producing k. pneumoniae: Convergence of two evolutionary mechanisms creates the "perfect storm"spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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