Diseño y caracterización de hidrogeles empleando Eichhornia crassipes (buchón de agua)

Briceño Barón, Andrea Nicole; Molina Rodríguez, Angelly Nicole; Quiñones Martinez, Maria Jose

Diseño y caracterización de hidrogeles empleando Eichhornia crassipes (buchón de agua)

dc.contributor.advisor	Jiménez Cruz, Ronald Andrés
dc.contributor.advisor	Millán Cortés, Diana Milena
dc.contributor.author	Briceño Barón, Andrea Nicole
dc.contributor.author	Molina Rodríguez, Angelly Nicole
dc.contributor.author	Quiñones Martinez, Maria Jose
dc.date.accessioned	2024-05-15T18:34:49Z
dc.date.available	2024-05-15T18:34:49Z
dc.date.issued	2024-05
dc.description.abstract	La creciente demanda de alternativas a los hidrogeles sintéticos y la inconveniente proliferación de la Eichhornia crassipes que causa afectaciones al medio ambiente, parecen ser dos problemáticas que se pueden solventar entre sí. Este estudio pretendía evaluar la viabilidad de esta planta invasora como fuente de celulosa para la fabricación de hidrogeles físicos de uso tópico. Para ello, se obtuvieron cuatro prototipos mediante variaciones de la metodología Organosolv, los cuales fueron caracterizados farmacotécnicamente y reológicamente. Los ensayos revelaron que cada prototipo obtenido se trataba de un hidrogel, con un contenido de agua superior al 92%, determinado por pérdida por secado, y un rendimiento del 31.1% ± 4.9%. La esparcibilidad señaló el prototipo B como semifluido, mientras que las pruebas reológicas determinaron que entre los prototipos no hay diferencias significativas y son pseudoplásticos garantizando el uso como hidrogeles tópicos. Además, todos los hidrogeles demostraron una baja citotoxicidad. Un análisis IR sugirió diferencias estructurales en cada uno de los hidrogeles, confirmando a su vez la prevalencia de celulosa. Se llevó a cabo un análisis de varianza (p < 0.05) para determinar cambios significativos. En conjunto, estos hallazgos sugieren que la Eichhornia crassipes es una fuente viable para la fabricación de hidrogeles.
dc.description.abstractenglish	The increasing demand for alternatives to synthetic hydrogels and the issue of Eichhornia crassipes' proliferation, which causes environmental damage, seem to be two problems that can be addressed by each other. This study aimed to evaluate the feasibility of utilizing this invasive plant as a source of cellulose for the fabrication of topical-use physical hydrogels. Four prototypes were synthesized via variations of the Organosolv methodology and subsequently subjected to pharmaceutical characterization. The experimental assays demonstrated that each prototype constituted a hydrogel, characterized by a water content exceeding 92%, as determined through drying loss, with a yield of 31.1% ± 4.9%. Evaluation of spreadability indicated the suitability of prototype B, while rheological assessments determined that there were no significant differences among the prototypes and they were all pseudoplastic, enserió their use as topical hydrogels. Furthermore, all hydrogels exhibited low cytotoxicity. Infrared spectroscopy revealed distinctive structural variances among the hydrogel formulations, confirming the predominance of cellulose. Statistical analysis, conducted via analysis of variance (p < 0.05), underscored significant differences. Collectively, these findings display the potential of Eichhornia crassipes as a viable cellulose source for hydrogel production.
dc.description.degreelevel	Pregrado	spa
dc.description.degreelevel	Químico Farmacéutico	spa
dc.format.mimetype	application/pdf
dc.identifier.instname	Universidad El Bosque	spa
dc.identifier.reponame	reponame:Repositorio Institucional Universidad El Bosque	spa
dc.identifier.repourl	repourl:https://repositorio.unbosque.edu.co
dc.identifier.uri	https://hdl.handle.net/20.500.12495/12118
dc.language.iso	es
dc.publisher.faculty	Facultad de Ciencias	spa
dc.publisher.grantor	Universidad El Bosque	spa
dc.publisher.program	Química Farmacéutica	spa
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dc.rights	Attribution 4.0 International	en
dc.rights.accessrights	info:eu-repo/semantics/openAccess
dc.rights.accessrights	http://purl.org/coar/access_right/c_abf2
dc.rights.local	Acceso abierto	spa
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Hidrogel físico
dc.subject	Celulosa
dc.subject	Eichhornia crassipes
dc.subject	Uso tópico
dc.subject	Biomasa
dc.subject	Material lignocelulósico
dc.subject.ddc	615.19
dc.subject.keywords	Physical hydrogel
dc.subject.keywords	Cellulose
dc.subject.keywords	Eichhornia crassipes
dc.subject.keywords	Topical use
dc.subject.keywords	Biomass
dc.subject.keywords	Lignocellulosic material
dc.title	Diseño y caracterización de hidrogeles empleando Eichhornia crassipes (buchón de agua)
dc.title.translated	Design and characterization of hydrogels using Eichhornia crassipes (water hyacinth)
dc.type.coar	https://purl.org/coar/resource_type/c_7a1f
dc.type.coarversion	https://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driver	info:eu-repo/semantics/bachelorThesis
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion
dc.type.local	Tesis/Trabajo de grado - Monografía - Pregrado