Daptomycin for the treatment of bacteraemia due to vancomycin-resistant enterococci

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dc.contributor.authorMurray, Barbara E.
dc.contributor.authorArias, Cesar A.
dc.contributor.authorMunita, Jose M.
dc.date.accessioned2020-07-06T17:33:17Z
dc.date.available2020-07-06T17:33:17Z
dc.date.issued2014
dc.description.abstractenglishTreatment of severe infections caused by vancomycin-resistant enterococci (VRE) is challenging due to the scarcity of reliable therapeutic alternatives.Inthis context,daptomycin(DAP), a lipopeptide antibiotic, has emerged as an interesting alternative as itis one ofthe few compounds that retain in vitro bactericidal activity against VRE isolates, although it has not been approved for this purpose by regulatory agencies. In this review, we will summarise the clinical, animal and in vitro evidence evaluating the efficacy of DAP for the management of deep-seated VRE infections. In addition, we will address important clinical concerns such as the emergence of DAP resistance during therapy and reports of therapeutic failure with DAP monotherapy. Finally, we will discuss possible future strategies (such as the use of higher doses and/or combination therapies) to optimise the use of this antibiotic against VRE.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijantimicag.2014.08.002
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0924-8579
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3325
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalInternational Journal of Antimicrobial Agentsspa
dc.relation.ispartofseriesInternational Journal of Antimicrobial Agents, 0924-8579, Vol. 44, Nro. 5, 2014, p. 387-395spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0924857914002519?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2014
dc.rights.localAcceso abiertospa
dc.subject.decsDaptomicinaspa
dc.subject.decsEnterococos resistentes a la vancomicinaspa
dc.subject.decsBacteriemiaspa
dc.subject.keywordsDaptomycinspa
dc.subject.keywordsVREspa
dc.subject.keywordsEnterococcal bacteraemiaspa
dc.subject.keywordsEnterococcispa
dc.titleDaptomycin for the treatment of bacteraemia due to vancomycin-resistant enterococcispa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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