Factors predictive of high disease activity early in the course of SLE in patients from a Latin-American cohort

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dc.contributor.authorPimentel-Quiroz, Victor R.
dc.contributor.authorUgarte-Gil, Manuel F.
dc.contributor.authorPons-Estel, Guillermo J.
dc.contributor.authorSoriano, Enrique R.
dc.contributor.authorSaurit, Verónica
dc.contributor.authorSato, Emilia I.
dc.contributor.authorLavras Costallat, Lilian T.
dc.contributor.authorMolina, José Fernando
dc.contributor.authorIglesias-Gamarra, Antonio
dc.contributor.authorReyes-Llerena, Gil
dc.contributor.authorNeira, Oscar J.
dc.contributor.authorBarile, Leonor A.
dc.contributor.authorSilveira, Luis H.
dc.contributor.authorSegami, María Ines
dc.contributor.authorChacón-Díaz, Rosa
dc.contributor.authorWojdyla, Daniel
dc.contributor.authorAlarcón, Graciela S.
dc.contributor.authorPons-Estel, Bernardo A.
dc.date.accessioned2020-11-05T20:02:54Z
dc.date.available2020-11-05T20:02:54Z
dc.description.abstractenglishTo determine the factors predictive of disease activity early in the course of SLE (baseline visit). Patients from GLADEL, a multi-national, multi-ethnic, Latin-American lupus cohort were included. Disease activity was evaluated at baseline with the SLEDAI score. Demographic characteristics (age at diagnosis, gender, ethnicity, marital status, educational level, medical coverage and socioeconomic status) were assessed. Disease duration was defined as the time between the fourth ACR criterion and baseline. Time to criteria accrual was defined as the interval between the first and fourth ACR criterion. Use of glucocorticoids was recorded as the highest dose received before the baseline visit. Antimalarials and immunosuppressive drugs were recorded as use or not use. Univariable and multivariable analysis were performed. Model selection was based on backward elimination. One thousand two hundred sixty-eight patients were included; 1136 (89.6%) of them were female. Mean age at diagnosis was 29.2 (SD: 12.3) years. Five hundred sixty-five (44.6%) were Mestizo, 539 (42.5%) were Caucasians and 164 (12.9%) were African-Latin-Americans. The mean SLEDAI at baseline was 10.9 (SD: 8.4). Longer time between first and fourth ACR criterion, medical coverage, a dose of prednisone between 15 and 60mg/d, and the use of antimalarials were factors protective of disease activity, while Mestizo and African-Latin-American ethnicities were predictive factors. Mestizo and African-Latin-American ethnicities were predictive whereas antimalarial use, medical coverage, and longer time to criteria accrual were protective of higher disease activity early in the disease course.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.semarthrit.2017.01.012
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1532-866X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4639
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalSeminars in Arthritis & Rheumatismspa
dc.relation.ispartofseriesSeminars in Arthritis & Rheumatism, 1532-866X, Vol. 47, No. 2, 2017, p. 199-203spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0049017216301779?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.subject.keywordsAntimalarial usespa
dc.subject.keywordsDisease activityspa
dc.subject.keywordsEthnic groupspa
dc.subject.keywordsSystemic lupus erythematosusspa
dc.titleFactors predictive of high disease activity early in the course of SLE in patients from a Latin-American cohortspa
dc.title.translatedFactors predictive of high disease activity early in the course of SLE in patients from a Latin-American cohortspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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