Quimiosensores: una alternativa para la detección de antibióticos y antimicóticos en aguas para la prevención de la resistencia antimicrobiana

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dc.contributor.advisorSarmiento Monsalve, Jeymy Tatiana
dc.contributor.authorParra Riaño, Allison Gabriela
dc.contributor.authorRamos Vásquez, Ana María
dc.date.accessioned2024-11-20T16:47:34Z
dc.date.available2024-11-20T16:47:34Z
dc.date.issued2024-10
dc.description.abstractLos antimicrobianos, hoy en día, representan uno de los problemas más grandes relacionados con la contaminación ocasionada por desechos de productos farmacéuticos, encontrados en diversas matrices ambientales, dentro de las cuales están las fuentes hídricas. Estas fuentes hídricas son las matrices de mayor preocupación actual, debido a que, tienen la capacidad de proporcionar condiciones favorables para la propagación de genes de resistencia antimicrobiana. Esta contaminación representa un gran problema de salud pública, cuyo efecto principal es el aumento de patógenos con resistencia adquirida dificultando así su tratamiento y manejo médico. Por lo tanto, es de suma importancia buscar alternativas que permitan realizar una detección temprana, adecuada, económica y sencilla de diferentes agentes antimicrobianos en entornos acuáticos. Los quimiosensores son una alternativa para la detección de estos agentes, ya que, presentan una gran variedad de ventajas, como: simplicidad, detección a simple vista, debido a que no requiere la utilización de instrumentos costosos y su respuesta es rápida. En el presente trabajo de grado se recopila información de los últimos avances científicos en la investigación, síntesis y desarrollo de quimiosensores usados para la detección de antimicrobianos en fuentes hídricas, clasificándolos y explicando el tipo de antimicrobiano que tienen la capacidad de detectar, sus mecanismos de detección, características y ventajas frente a las metodologías usadas en la actualidad, esto se realizará a través de una revisión bibliográfica en diferentes bases de datos como: ProQuest One Academic, Science Direct, Reaxys y Pubmed utilizando herramientas para la selección de los artículos científicos a revisar, como lo son: operadores booleanos, criterios de inclusión y exclusión, seleccionando un total de 60 artículos que fueron revisados minuciosamente para su análisis. Finalmente, se logró identificar los mecanismos de detección principales por los cuales los quimiosensores tienen la capacidad de detectar las diferentes familias de antimicrobianos generando una señal inmediata, siendo los más utilizados: el efecto de filtro interno (IFE) y la transferencia de electrones fotoinducida (PET), además de describir los diferentes quimiosensores para la detección de antimicrobianos en fuentes hídricas identificando tres grupos importantes que han sido desarrollados y sintetizados en los últimos años, los cuales son: quimiosensores fluorimétricos, colorimétricos y electroquímicos, cumpliendo un papel fundamental en la prevención de la resistencia antimicrobiana, por su capacidad para detectar muestras de forma no destructiva, rápida y selectiva.
dc.description.abstractenglishAntimicrobials, nowadays, represent one of the biggest problems related to contamination caused by waste pharmaceuticals found in various environmental matrices, among which are water sources. These water sources are the matrices of greatest current concern because they have the capacity to provide favorable conditions for the propagation of antimicrobial resistance genes. This contamination represents a major public health problem, whose main effect is the increase of pathogens with acquired resistance, thus making their treatment and medical management more difficult. Therefore, it is of utmost importance to look for alternatives that allow early, adequate, economical and simple detection of different antimicrobial agents in aquatic environments. Chemosensors are an alternative for the detection of these agents, since they present a great variety of advantages, such as: simplicity, detection at a glance, because they do not require the use of expensive instruments and their response is fast. In this degree work, information on the latest scientific advances in research, synthesis and development of chemosensors used for the detection of antimicrobials in water sources is compiled, classifying them and explaining the type of antimicrobial that have the ability to detect, their detection mechanisms, characteristics and advantages over the methodologies currently used, this will be done through a literature review in different databases such as: ProQuest One Academic, Science Direct, Reaxys and Pubmed using tools for the selection of scientific articles to be reviewed, such as: Boolean operators, inclusion and exclusion criteria, selecting a total of 60 articles that were thoroughly reviewed for analysis. Finally, it was possible to identify the main detection mechanisms by which the chemosensors have the capacity to detect the different families of antimicrobials generating an immediate signal, being the most used: Internal Filter Effect (IFE) and Photoinduced Electron Transfer (PET), in addition to describing the different chemosensors for the detection of antimicrobials in water sources identifying three important groups that have been developed and synthesized in recent years, which are: fluorimetric, colorimetric and electrochemical chemosensors, fulfilling a fundamental role in the prevention of antimicrobial resistance, for their ability to detect samples in a non-destructive, rapid and selective manner.
dc.description.degreelevelPregradospa
dc.description.degreelevelQuímico Farmacéuticospa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/13272
dc.language.isoes
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programQuímica Farmacéuticaspa
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dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntimicrobianos
dc.subjectAntimicóticos
dc.subjectAntibióticos
dc.subjectDetección
dc.subjectQuimiosensor
dc.subjectAgua
dc.subject.ddc615.19
dc.subject.keywordsAntimicrobials
dc.subject.keywordsAntifungicals
dc.subject.keywordsAntibiotics
dc.subject.keywordsDetection
dc.subject.keywordsChemosensor
dc.subject.keywordsWater
dc.titleQuimiosensores: una alternativa para la detección de antibióticos y antimicóticos en aguas para la prevención de la resistencia antimicrobiana
dc.title.translatedChemosensors: an alternative for the detection of antibiotics and antifungals in water for the prevention of antimicrobial resistance
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesis/Trabajo de grado - Monografía - Pregrado

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Química Farmacéutica