Phylogenomic classification and the evolution of clonal complex 5 Methicillin-Resistant Staphylococcus aureus in the Western Hemisphere

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dc.contributor.authorChallagundla, Lavanya
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorRafiqullah, Iftekhar
dc.contributor.authorSordelli, Daniel O.
dc.contributor.authorEchaniz-Aviles, Gabriela
dc.contributor.authorVelazquez-Meza, Maria E.
dc.contributor.authorCastillo-Ramírez, Santiago
dc.contributor.authorFittipaldi, Nahuel
dc.contributor.authorFeldgarden, Michael
dc.contributor.authorChapman, Sinéad B.
dc.contributor.authorCalderwood, Michael S.
dc.contributor.authorCarvajal Ortiz, Lina Paola
dc.contributor.authorRincón, Sandra
dc.contributor.authorHanson, Blake
dc.contributor.authorPlanet, Paul J.
dc.contributor.authorArias, César A.
dc.contributor.authorDíaz, Lorena
dc.contributor.authorRobinson, D. Ashley
dc.contributor.orcidCarvajal Ortiz, Lina Paola [0000-0001-8301-8836]
dc.date.accessioned2019-08-14T16:10:52Z
dc.date.available2019-08-14T16:10:52Z
dc.date.issued2018
dc.description.abstractenglishClonal complex 5 methicillin-resistant Staphylococcus aureus (CC5-MRSA) includes multiple prevalent clones that cause hospital-associated infections in the Western Hemisphere. Here, we present a phylogenomic study of these MRSA to reveal their phylogeny, spatial and temporal population structure, and the evolution of selected traits. We studied 598 genome sequences, including 409 newly generated sequences, from 11 countries in Central, North, and South America, and references from Asia and Europe. An early-branching CC5-Basal clade is well-dispersed geographically, is methicillin-susceptible and MRSA predominantly of ST5-IV such as the USA800 clone, and includes separate subclades for avian and porcine strains. In the early 1970s and early 1960s, respectively, two clades appeared that subsequently underwent major expansions in the Western Hemisphere: a CC5-I clade in South America and a CC5-II clade largely in Central and North America. The CC5-I clade includes the ST5-I Chilean/Cordobes clone, and the ST228-I South German clone as an early offshoot, but is distinct from other ST5-I clones from Europe that nest within CC5-Basal. The CC5-II clade includes divergent strains of the ST5-II USA100 clone, various other clones, and most known vancomycin-resistant strains of S. aureus, but is distinct from ST5-II strain N315 from Japan that nests within CC5-Basal. The recombination rate of CC5 was much lower than has been reported for other S. aureus genetic backgrounds, which indicates that recurrence of vancomycin resistance in CC5 is not likely due to an enhanced promiscuity. An increased number of antibiotic resistances and decreased number of toxins with distance from the CC5 tree root were observed. Of note, the expansions of the CC5-I and CC5-II clades in the Western Hemisphere were preceded by convergent gains of resistance to fluoroquinolone, macrolide, and lincosamide antibiotics, and convergent losses of the staphylococcal enterotoxin p (sep) gene from the immune evasion gene cluster of phage ϕSa3. Unique losses of surface proteins were also noted for these two clades. In summary, our study has determined the relationships of different clades and clones of CC5 and has revealed genomic changes for increased antibiotic resistance and decreased virulence associated with the expansions of these MRSA in the Western Hemisphere.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fmicb.2018.01901
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1664-302X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1608
dc.language.isoeng
dc.publisherFrontiersspa
dc.publisher.journalFrontiers in microbiologyspa
dc.relation.ispartofseriesFrontiers in microbiology, 1664-302X, 2018spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2018.01901/full
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf451
dc.rights.creativecommons2018
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsInfección hospitalariaspa
dc.subject.decsVirulenciaspa
dc.subject.decsFarmacorresistencia microbianaspa
dc.subject.keywordsMethicillin-resistant staphylococcus aureusspa
dc.subject.keywordsMRSAspa
dc.subject.keywordsPhylogenomicsspa
dc.titlePhylogenomic classification and the evolution of clonal complex 5 Methicillin-Resistant Staphylococcus aureus in the Western Hemispherespa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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