Characterization of macrolide resistance in Gram-positive cocci from Colombian hospitals: a countrywide surveillance

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dc.contributor.authorReyes, Jinnethe
dc.contributor.authorHidalgo, Marylin
dc.contributor.authorDiaz, Lorena
dc.contributor.authorRincon Núñez, Sandra
dc.contributor.authorMoreno, Jaime Enrique
dc.contributor.authorVanegas, Natasha
dc.contributor.authorCastañeda, Elizabeth
dc.contributor.authorArias, César A.
dc.contributor.orcidRincon Núñez, Sandra [0000-0002-8482-4554]
dc.date.accessioned2020-05-13T22:37:25Z
dc.date.available2020-05-13T22:37:25Z
dc.date.issued2007
dc.description.abstractenglishObjective The characterization of macrolide resistance in Gram-positive cocci recovered from Colombian hospitals. Methods The resistance profiles and mechanism of macrolide resistance were investigated in isolates of Streptococcus pneumoniae (1679), Staphylococcus aureus (348), coagulase-negative staphylococci (CoNS) (175), and Enterococcus spp (123). Minimum inhibitory concentrations (MICs) for erythromycin (ERY) and clindamycin (CLI), detection of macrolide resistance genes, phenotypic characterization, and pulsed field gel electrophoresis (PFGE) of macrolide-resistant pneumococci were performed. Results Resistance to ERY and CLI was 3.3% and 2.3% for S. pneumoniae , 58% and 57% for S. aureus (94% for both compounds in methicillin-resistant Staphylococcus aureus (MRSA)), and 78.6% and 60.7% in methicillin-resistant Staphylococcus epidermidis , respectively. ERY resistance was 62% in Enterococcus faecalis and 82% in Enterococcus faecium . The MLS B -type accounted for 71% of S. pneumoniae and 100% of MRSA. The erm (A) gene was prevalent in MRSA, erm (B) in S. pneumoniae and enterococci, and erm (C) in CoNS isolates. Efflux pump genes ( mef (A) genes) were mostly identified in S. pneumoniae (24%). The most common genotype amongst ERY-resistant pneumococci was the Spain 6B -2 clone. Conclusions The prevalence of macrolide resistance is low in Colombian pneumococci and high in MRSA (cMLS B -type).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2006.09.005
dc.identifier.issn1201-9712
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2736
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalInternational Journal of Infectious Diseasesspa
dc.relation.ispartofseriesInternational Journal of Infectious Diseases, 1201-9712, Vol.11, Nro. 4, 2007, p.329-336spa
dc.relation.urihttps://www.ijidonline.com/article/S1201-9712(06)00168-8/fulltext
dc.rights.creativecommons2007
dc.rights.localAcceso cerradospa
dc.subject.decsGenes bacterianosspa
dc.subject.decsEnterococcus faecalisspa
dc.subject.decsEncuestas epidemiológicasspa
dc.subject.keywordsMacrolidesspa
dc.subject.keywordsAntimicrobial drug resistancespa
dc.subject.keywordsStreptococcus pneumoniaespa
dc.titleCharacterization of macrolide resistance in Gram-positive cocci from Colombian hospitals: a countrywide surveillancespa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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