Adiponectin, leptin and TNF-α serum levels in obese and normal weight Peruvian adults with and without chronic periodontitis

Vista sencilla de ítem
dc.contributor.authorMendoza-Azpur, Gerardo
dc.contributor.authorCastro, Carmen
dc.contributor.authorPeña, Lizet
dc.contributor.authorGuerrero, Maria-Eugenia
dc.contributor.authorDe La Rosa, Manuel
dc.contributor.authorMendes, Claudio
dc.contributor.authorChambrone, Leandro
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.date.accessioned2020-08-06T18:14:57Z
dc.date.available2020-08-06T18:14:57Z
dc.date.issued2015
dc.description.abstractenglishBackground TNF-α, an adipokine involved in systemic inflammation and a member of a group of cytokines that stimulate the acute phase reaction, has been related to the pathogenesis of both periodontitis and obesity. The objective of this study was to assess the serum levels of adiponectin, leptin and TNF-α of periodontally healthy normal weight (NW) patients, NW patients with chronic periodontitis (CP), periodontally healthy obese patients and obese patients with CP. Material and Methods Ninety-three patients were enrolled in this cross-sectional study: 30 periodontally healthy NW patients; 18 NW patients with CP; 21 periodontally healthy obese patients; and 24 obese patients with CP. Analyses included clinical and anthropometric outcomes, as well as the assessment of serum levels of adiponectin, leptin and TNF-α by enzyme linked immunosorbent assay (ELISA) or fully automated chemiluminescence immunoassay. One-Way ANOVA, Kruskal-Wallis One-Way on Ranks, Dunn’s Test and multivariable logistic regression (MLR) analyses were conducted to estimate the degree of association between periodontitis and obesity. Results Obese patients with CP showed significant more bleeding sites than the other three groups (p<0.05). Moreover, patients from the NWCP and OPH showed similar BOP percentages, as well as OPH group showed more bleeding sites than the NWPH group (p<0.05). The OPH group showed similar levels of adiponectin and leptin than the OCP group, but significantly higher than the NWPH and NWCP groups(p<0.05). MLR analyses showed that obesity was positively associated with the percentage of sites with bleeding on probing, with an odds ratio of 0.93 (95% confidence interval: -0.88, - 0.98; p=0.012). Conclusions The serum levels of adiponectin, leptin and TNF-α were not influenced by CP. Obese patients showed almost 10% more sites with BoP. In chronic periodontitis patients, obese subjects presented significant more BOP sites than normal weight subjects.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4317/jced.52350
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1989-5488
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3710
dc.language.isoeng
dc.publisherMedicina Oralspa
dc.publisher.journalJournal of clinical and experimental dentistryspa
dc.relation.ispartofseriesJournal of clinical and experimental dentistry, 1989-5488, Vol. 7, Nro. 3, 2015, p. 380–386spa
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554237/
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015-07
dc.rights.localAcceso abiertospa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsObesityspa
dc.subject.keywordsInflammationspa
dc.subject.keywordsAdiponectinspa
dc.subject.keywordsLeptinspa
dc.titleAdiponectin, leptin and TNF-α serum levels in obese and normal weight Peruvian adults with and without chronic periodontitisspa
dc.title.translatedAdiponectin, leptin and TNF-α serum levels in obese and normal weight Peruvian adults with and without chronic periodontitisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Mendoza-Azpur, Gerardo.pdf
Tamaño:
509.21 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos