A low-cost electrochemical biosensor platform for C-reactive protein detection

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dc.contributor.authorGuillem, Pedro
dc.contributor.authorBustos, Rosa Helena
dc.contributor.authorGarzon, Vivian
dc.contributor.authorMunoz, Andres
dc.contributor.authorJuez, Graciela
dc.date.accessioned2021-03-08T16:35:20Z
dc.date.available2021-03-08T16:35:20Z
dc.date.issued2021
dc.description.abstractenglishAntibiotic resistance is a worldwide problem aggravated by the overuse of prophylactic antibiotic therapies and lack of real-time biosensing equipment to differentiate viral from bacterial infections at the Point of Care (POC), particularly in rural areas with limited access to clinical laboratory facilities. As recent studies reveal the potential of C-Reactive Protein (CRP) and other acute phase biomarkers to achieve early determination of etiology in acute febrile illness, novel biosensing equipment become a plausible approach in preventing the unnecessary prescription of antibiotics. A low-cost experimental platform was engineered to measure CRP concentrations in 50 μL samples of buffer and enriched plasma, using label-free antigenic probes, legacy electrochemical methods and open-source hardware. The prototype presents a portable, cost-effective device for use at the POC with a simplified user interface that can be used wirelessly by healthcare professionals using a mobile phone or laptop. Based on the measured CRP levels, the device suggests if the acute febrile episode is likely to be of bacterial etiology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.sbsr.2021.100402
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2214-1804
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5568
dc.language.isoeng
dc.publisherElsevier B.V.spa
dc.publisher.journalSensing and Bio-Sensing Researchspa
dc.relation.ispartofseriesSensing and Bio-Sensing Research, 2214-1804, Vol. 31, 2021 p. 100402spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2214180421000076?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2021
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.keywordsElectrochemical biosensorspa
dc.subject.keywordsAntibiotic resistancespa
dc.subject.keywordsCRPspa
dc.subject.keywordsPoint-of-care diagnosticsspa
dc.titleA low-cost electrochemical biosensor platform for C-reactive protein detectionspa
dc.title.translatedA low-cost electrochemical biosensor platform for C-reactive protein detectionspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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