Establishment and multi drug resistance evolution of ST235 Pseudomonas aeruginosa strains in the intensive care unit of a Colombian hospital

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Martinez_Elena_2014.pdf (245.74 KB)

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2014

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Publicado en

Research in Microbiology, 0923-2508, Vol. 165, Nro. 10, 2014, p. 852 - 856

Publicado por

Elsevier Masson

URI

https://hdl.handle.net/20.500.12495/3341

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https://www.sciencedirect.com/science/article/pii/S0923250814002137

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Abstract

Drug resistant Pseudomonas aeruginosa represents a therapeutic challenge. To assess the diversity of P. aeruginosa antibiotic resistant variants, isolates were recovered from hospital patients in Colombia. Thirty of 60 isolates contained class 1 integrons and five were of Sequence Type ST235 having appeared in a single intensive care unit. All five possessed an unusual integron but showed differences in gene cassette content and the presence/absence of insertion sequence IS26. This showed that differences can arise rapidly, even within a single ICU. Also, the emergence of IS26 in P. aeruginosa is contributing to the evolution of resistance in this bacterium.

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Keywords

Pseudomonas aeruginosa ST235, IS26, Antibiotic resistance, Hospital acquired infections

Temáticas

Infecciones bacterianas
Farmacorresistencia microbiana
Pseudomonas aeruginosa

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