An international epidemiological analysis of young patients with non-small cell lung cancer (AduJov-CLICaP)

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dc.contributor.authorCorrales-Rodríguez, Luis
dc.contributor.authorArrieta, Oscar
dc.contributor.authorMas, Luis Alberto
dc.contributor.authorBáez-Saldaña, Renata
dc.contributor.authorCastillo-Fernandez, Omar
dc.contributor.authorBlais, Normand
dc.contributor.authorMartín, Claudio Marcelo
dc.contributor.authorJuárez, Melissa
dc.contributor.authorKhanna, Priyanka
dc.contributor.authorRamos-Esquivel, Allan
dc.contributor.authorBacon, Ludwing
dc.contributor.authorRojas Puentes, Leonardo
dc.contributor.authorWills, Beatriz
dc.contributor.authorOblitas, George
dc.contributor.authorPérez, María Angelina
dc.contributor.authorCuello, Mauricio
dc.contributor.authorCardona-Mendoza, Andrés Felipe
dc.contributor.orcidCardona-Mendoza, Andrés Felipe [0000-0002-6697-5471]
dc.contributor.orcidRojas Puentes, Leonardo [0000-0002-7865-5424]
dc.date.accessioned2020-06-16T18:57:24Z
dc.date.available2020-06-16T18:57:24Z
dc.description.abstractenglishBackground A proportion of patients with NSCLC is diagnosed at 40 years or younger. These patients tend to be never-smokers, usually present with stage IV adenocarcinoma, and have somatic genomic alterations. Few studies have documented and analyzed epidemiological characteristics of this population. Materials and methods We performed an international epidemiological analysis of 389 young patients with NSCLC. Data was collected from centers participating in the Latin American Consortium for Lung Cancer Research (AduJov-CLICaP). Patients were identified and data was retrospectively collected from different Latin American countries and Canada (Argentina = 6, Canada = 19, Colombia = 29, Costa Rica = 9, Mexico = 219, Nicaragua = 2, Panama = 19, Perú = 76 and Venezuela = 10). The period of study was from 2012 to 2017. Inclusion criteria were: age 40 years or less and a histologically confirmed NSCLC. Clinical data was obtained, and EGFR mutation status and EML4-ALK translocation were collected. Results NSCLC patients aged 40 years or less accounted for approximately 4% of the total NSCLC population. Female patients accounted for 54.5%, while median age was of 37 years. Adenocarcinoma accounted for 86.1% (n = 335/389), 72.5% (n = 282/389; unknown = 5) of patients were non-smokers, and 90.3% (n = 351/389) had stage IV disease. Site of metastasis was obtained from 260/351 (unknown = 91) stage IV patients (lung metastasis = 40.0%, CNS metastasis = 35.7%, and bone metastasis = 31.5%). OS for the total population was 17.3 months (95%CI = 13.9-20.7). OS for EGFRm(+) = 31.4 months (95%CI = 11.6-51.3), EGFRm(−) = 14.5 months (95%CI = 11.0–17.9) (p = 0.005). OS for alk(+) = 9.8 months (95%CI = 3.1-16.5) and alk(−) = 5.6months (95%CI = 3.9–7.3) (p = 0.315). Conclusions Patients aged 40 years or less account for a small but important proportion of NSCLC cases. Younger patients may have different characteristics compared to the older population. EGFRm and EML4-alk translocation frequency is higher than that of the general population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.lungcan.2017.08.022
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1872-8332
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3194
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalLung cancerspa
dc.relation.urihttps://www.lungcancerjournal.info/article/S0169-5002(17)30497-X/fulltext
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-08-28
dc.rights.localAcceso abiertospa
dc.subject.decsNeoplasias pulmonaresspa
dc.subject.decsCarcinoma de pulmón de células no pequeñasspa
dc.subject.decsNo fumadoresspa
dc.subject.keywordsNSCLCspa
dc.subject.keywordsYoungspa
dc.subject.keywordsAdenocarcinomaspa
dc.titleAn international epidemiological analysis of young patients with non-small cell lung cancer (AduJov-CLICaP)spa
dc.title.translatedAn international epidemiological analysis of young patients with non-small cell lung cancer (AduJov-CLICaP)spa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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