Efficacy of telavancin alone and in Combination with ampicillin in a rat model of enterococcus faecalis endocarditis

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dc.contributor.authorTran, Truc T.
dc.contributor.authorTam, Vincent H.
dc.contributor.authorMurray, Barbara E.
dc.contributor.authorArias, Cesar A.
dc.contributor.authorSingh, Kavindra V.
dc.date.accessioned2020-08-06T19:20:01Z
dc.date.available2020-08-06T19:20:01Z
dc.description.abstractenglishWe first assessed telavancin (TLV) pharmacokinetics in rats after a single subcutaneous dose of 35 mg/kg of body weight. The pharmacokinetic data were used to predict a TLV dose that simulates human exposure, and the efficacy of TLV was then evaluated using a TLV dose of 21 mg/kg every 12 h against Enterococcus faecalis OG1RF (TLV MIC of 0.06 g/ml) in a rat endocarditis model with an indwelling catheter. Therapy was given for 3 days with TLV, daptomycin (DAP), or ampicillin (AMP) monotherapy and with combinations of TLV plus AMP, AMP plus gentamicin (GEN), and AMP plus ceftriaxone (CRO); rats were sacrificed 24 h after the last dose. Antibiotics were given to simulate clinically relevant concentrations or as used in other studies. TLV treatment resulted in a significant decrease in bacterial burden (CFU per gram) in vegetations from 6.0 log10 at time 0 to 3.1 log10 after 3 days of therapy. Bacterial burdens in vegetations were also significantly lower in the TLVtreated rats than in the AMP (P 0.0009)- and AMP-plus-GEN (P 0.035)-treated rats but were not significantly different from that of the AMP-plus-CRO-treated rats. Bacterial burdens from vegetations in TLV monotherapy and TLV-plus-AMP-and-DAP groups were similar to each other (P 0.05). Our data suggest that further study of TLV as a therapeutic alternative for deep-seated infections caused by vancomycinsusceptible E. faecalis is warranted.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/AAC.02489-16
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3717
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial Agents and Chemotherapyspa
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy, 1098-6596, Vol. 61, Nro. 6, 2017, p. 1-9spa
dc.relation.urihttps://aac.asm.org/content/61/6/e02489-16.long
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-06
dc.rights.localAcceso abiertospa
dc.subject.keywordsTelavancinspa
dc.subject.keywordsEnterococcus faecalisspa
dc.subject.keywordsTherapyspa
dc.subject.keywordsRat endocarditisspa
dc.titleEfficacy of telavancin alone and in Combination with ampicillin in a rat model of enterococcus faecalis endocarditisspa
dc.title.translatedEfficacy of telavancin alone and in Combination with ampicillin in a rat model of enterococcus faecalis endocarditisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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