Predictive factors related to the progression of periodontal disease in patients with early rheumatoid arthritis: A cohort study

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dc.contributor.authorHeredia-P, Ana María
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorTrujillo Escobar, Tamy Goretty
dc.contributor.authorChalem-Choueka, Philippe
dc.contributor.authorBello-Gualtero, Juan Manuel
dc.contributor.authorPacheco-Tena, Cesar
dc.contributor.authorChila, Lorena
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-03-27T17:26:27Z
dc.date.available2020-03-27T17:26:27Z
dc.date.issued2019
dc.description.abstractenglishBackground: Rheumatoid arthritis (RA) and periodontal disease are inter-related conditions. However, factors predictive of periodontal disease progression in patients with early rheumatoid arthritis (eRA) are lacking. The aim of this study was to identify factors associated with the progression of clinical attachment loss (CAL) in interproximal dental sites of eRA patients. Methods: Twenty-eight eRA patients were evaluated for the progression of CAL at 280 interproximal dental sites at 1 year of follow-up. Markers of RA activity (rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein), a marker of bone resorption (Dickkopf-related protein 1), Disease Activity Score 28 and Simple Disease Activity Index were included as potential systemic predictive factors. Plaque index, gingival index, pocket depth, clinical attachment level and Dickkopf-related protein 1 in crevicular fluid at baseline were included as potential local predictive factors. Data were analysed in a hierarchical structure using generalised linear mixed models for progression at each site (> 2 mm) during follow-up. Results: C-reactive protein level was the most important predictive systemic factor for the progression of CAL. The mean CAL and a high degree of gingival inflammation in interproximal sites at baseline were important predictive local factors (p < 0.0001). Patients who received combined treatment with disease-modifying antirheumatic drugs and corticosteroids exhibited less CAL (p < 0.0001). The predictive value of the generalised linear mixed model for progression was 85%. Conclusions: Systemic factors, including RA disease activity and baseline periodontal condition, were associated with periodontal progression. Pharmacological treatment may affect periodontal progression in patients with early RA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12903-019-0939-6
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1472-6831
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2174
dc.language.isoeng
dc.publisherBioMed centralspa
dc.publisher.journalBMC oral healthspa
dc.relation.ispartofseriesBMC oral health, 1472-6831. Vol. 19, Nro. 1, 2019spa
dc.relation.uribmcoralhealth.biomedcentral.com/articles/10.1186/s12903-019-0939-6#Abs1
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf167
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsArtritis reumatoidespa
dc.subject.decsPeriodontitisspa
dc.subject.decsEstudios de casosspa
dc.subject.keywordsDAS28spa
dc.subject.keywordsC-reactive proteinspa
dc.subject.keywordsDickkopf-related protein 1spa
dc.titlePredictive factors related to the progression of periodontal disease in patients with early rheumatoid arthritis: A cohort studyspa
dc.title.translatedPredictive factors related to the progression of periodontal disease in patients with early rheumatoid arthritis: A cohort study
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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Heredia-P A.M., Lafaurie G.I., Bautista-Molano W., Trujillo T.G., Chalem-Choueka P., Bello-Gualtero J.M., Pacheco-Tena C., Chila-Moreno L., Romero-Sánchez C.,_2019.pdf
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