Risk factors for reamputation in patients with diabetic foot: A case-control study

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dc.contributor.authorCorrea Sánchez, Carlos Alberto
dc.contributor.authorVargas-Hernández, Juan Sebastián
dc.contributor.authorGarcía, Luisa Fernanda
dc.contributor.authorJaimes, Julián
dc.contributor.authorCaicedo, Martha
dc.contributor.authorNiño, Manuel Eduardo
dc.contributor.authorRobledo Quijano, Jaime
dc.date.accessioned2023-07-19T16:42:29Z
dc.date.available2023-07-19T16:42:29Z
dc.date.issued2023
dc.description.abstractenglishBackground: Reamputation as a complication of diabetic foot ulcers presents a high economic burden and represents a therapeutic failure. It is paramount to identify as early as possible patients in whom a minor amputation may not be the best option. The purpose of this investigation was to do a case-controlled study to determine risk factors associated with re-amputation in patients with DFU (diabetic foot ulcers) at two University Hospitals. Methods: Multicentric, observational, retrospective, case-control study from clinical records of 2 university hospitals. Our study included 420 patients, with 171 cases (re-amputations), and 249 controls. We performed a multivariate logistic regression analysis and time-to-event survival analysis to identify re-amputation risk factors. Results: Statistically significant risk factors were artery history of tobacco use (p = 0.001); male sex (p = 0.048); arterial occlusion in Doppler ultrasound (p = 0.001); percentage of stenosis in arterial ultrasound >50 % (p = 0.053); requirement of vascular intervention (p = 0.01); and microvascular involvement in photoplethysmography (p = 0.033). The most parsimonious regression model suggests that history of tobacco use, male sex, arterial occlusion in ultrasound, and percentage of stenosis in arterial ultrasound >50 % remained statistically significant. The survival analysis identified earlier amputations in patients with larger occlusion in arterial ultrasound, high leukocyte count, and elevated ESR. Conclusion: Direct and surrogate outcomes in patients with diabetic foot ulcers identify vascular involvement as an important risk factor for reamputation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.fas.2023.05.006
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1460-9584
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/11084
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalFoot and Ankle Surgeryspa
dc.relation.ispartofseriesFoot and Ankle Surgery, 1460-9584, 29 (5), 2023, 412 - 418spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1268773123001005?pes=vor
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectReamputaciónspa
dc.subjectÚlcera de pie diabéticospa
dc.subjectPie diabéticospa
dc.subjectAmputación de extremidad inferiorspa
dc.subjectInfecciónspa
dc.subjectAnálisis de supervivenciaspa
dc.subject.keywordsReamputationspa
dc.subject.keywordsDiabetic foot ulcerspa
dc.subject.keywordsDiabetic footspa
dc.subject.keywordsLower extremity amputationspa
dc.subject.keywordsInfectionspa
dc.subject.keywordsSurvival analysisspa
dc.titleRisk factors for reamputation in patients with diabetic foot: A case-control studyspa
dc.title.translatedRisk factors for reamputation in patients with diabetic foot: A case-control studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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