Hegemony of economic values in conducting clinical trials with a placebo-control group to investigate the treatment of periodontitis in lower-middle-income countries

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dc.contributor.authorOvalle, Constanza E.
dc.contributor.orcidArdila, Carlos Martín [https://orcid.org/0000-0002-3663-1416]
dc.date.accessioned2022-03-05T20:10:55Z
dc.date.available2022-03-05T20:10:55Z
dc.date.issued2021
dc.description.abstractenglishThis article analyzes the bioethical implications of using a control/placebo group when conducting clinical trials (CTs) investigating the treatment of periodontitis. For this, the deductive method was used, proposing the interrelation of values, and a scoping systematic review was carried out. A total of 53% of the CTs reviewed were performed in low- and middle-income (LMI) countries, and 92% used a control/placebo group as a comparison group. Although there is a gold standard for the adjunctive treatment of periodontitis, the research ethics committees of most of the analyzed studies approved the use of control/placebo groups for the performance of CTs that did not explore new therapeutic alternatives. In some cases, the CT protocols were not approved by ethics committees, nor was informed consent used. In the LMI countries, a shorter period of recruitment was observed for patients who attended universities and public hospitals. Likewise, most of the CTs reviewed had public funding, a significant amount of which came from the pharmaceutical industry. Only one CT reported the low economic and educational level of its participants. Furthermore, none of the authors of the reviewed CTs declared conflicts of interest. Although the axiology of techno-science always takes into account at least the epistemic, technical and economic value systems, the hegemony of the economic values imposed by the pharmaceutical industry is evident in the performance of CTs investigating the treatment of periodontitis in LMI countries.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/dewb.12334
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1471-8731
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/7141
dc.language.isoeng
dc.publisherJohn Wiley and Sons Incspa
dc.publisher.journalDeveloping World Bioethicsspa
dc.relation.ispartofseriesDeveloping World Bioethics, 1471-8731, 2021spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/dewb.12334
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.subject.keywordsBioethicsspa
dc.subject.keywordsClinical trialsspa
dc.subject.keywordsDeveloping world bioethicsspa
dc.subject.keywordsDrug trialspa
dc.subject.keywordsLow-income populationspa
dc.subject.keywordsPlacebospa
dc.titleHegemony of economic values in conducting clinical trials with a placebo-control group to investigate the treatment of periodontitis in lower-middle-income countriesspa
dc.title.translatedHegemony of economic values in conducting clinical trials with a placebo-control group to investigate the treatment of periodontitis in lower-middle-income countriesspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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