Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages

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dc.contributor.authorPrada Arismendy, Jeanette
dc.contributor.authorRincón Forero, Verónica del Pilar
dc.contributor.authorCastellanos, Jaime
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.date.accessioned2019-08-27T13:34:19Z
dc.date.available2019-08-27T13:34:19Z
dc.date.issued2012
dc.description.abstractenglishInfection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 (DENV2). The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. Other molecular mechanisms related to flavivirus susceptibility remain to be explored.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2012/950303
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1687-9694
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1656
dc.language.isoeng
dc.publisherHindawi Publishing Corporationspa
dc.publisher.journalJournal of Tropical Medicinespa
dc.relation.ispartofseriesJournal of Tropical Medicine, 1687-9686, 2012, p. 1-7spa
dc.relation.urihttps://www.hindawi.com/journals/jtm/2012/950303/
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf264
dc.rights.creativecommons2012
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsVirus del denguespa
dc.subject.decsGenética microbianaspa
dc.subject.decsInfecciones por flavivirusspa
dc.titleComparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophagesspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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