Genotyping squamous cell lung carcinoma in Colombia (Geno1.1-CLICaP)

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dc.contributor.authorCardona-Mendoza, Andrés Felipe
dc.contributor.authorRuiz-Patinõ, Alejandro
dc.contributor.authorArrieta, Oscar
dc.contributor.authorRicaurte, Luisa María
dc.contributor.authorZatarain-Barrón, Zyanya Lucia
dc.contributor.authorRodríguez Ariza, July Katherine
dc.contributor.authorÁvila Coy, Jenny Mireya
dc.contributor.authorRojas Puentes, Leonardo
dc.contributor.authorRecondo, Gonzalo
dc.contributor.authorBarrón-Barrón, Feliciano
dc.contributor.authorArchila, Pilar
dc.contributor.authorSotelo-Rodríguez, Diana Carolina
dc.contributor.authorBravo Espinosa, Melissa Andrea
dc.contributor.authorZamudio, Nataly
dc.contributor.authorCorrales, Luis
dc.contributor.authorMartín, Claudio Marcelo
dc.contributor.authorRolfo, Christian
dc.contributor.authorViola Muñoz, Lucía
dc.contributor.authorCarranza, Hernán
dc.contributor.authorVargas Báez, Carlos Alberto
dc.contributor.authorOtero, Jorge Miguel
dc.contributor.authorBermúdez Díaz, Maritza Alejandra
dc.contributor.authorGamez, Tatiana
dc.contributor.authorPino, Luis Eduardo
dc.contributor.authorRosell, Rafael Costa
dc.contributor.orcidCardona-Mendoza, Andrés Felipe [0000-0002-6697-5471]
dc.contributor.orcidVargas Báez, Carlos Alberto [0000-0002-6076-8260]
dc.contributor.orcidRojas Puentes, Leonardo [0000-0002-7865-5424]
dc.contributor.orcidRodríguez Ariza, July Katherine [0000-0003-1168-595X]
dc.contributor.orcidSotelo-Rodríguez, Diana Carolina [0000-0002-7763-4760]
dc.contributor.orcidÁvila Coy, Jenny Mireya [0000-0002-2968-7980]
dc.contributor.orcidBermúdez Díaz, Maritza Alejandra [0000-0002-5870-0136]
dc.contributor.orcidViola Muñoz, Lucía [0000-0002-1647-2884]
dc.date.accessioned2021-02-13T14:40:32Z
dc.date.available2021-02-13T14:40:32Z
dc.description.abstractenglishBackground: Lung cancer is a public health problem, and squamous cell carcinoma (SCC) is the second most prevalent subtype of this neoplasm. Compared to other subtypes, including adenocarcinoma, SCC is less well understood in terms of molecular pathogenesis, limiting therapeutic options among targeted agents approved for other disease subgroups. In this study, we sought to characterize the SCC genomic profile using a validated Next Generation Sequencing (NGS) platform. Methods: The comprehensive NGS assay (TruSight Tumor 170) was used in order to target the full coding regions of 170 cancer-related genes on SCC samples. PD-L1 expression in tumor cells (TCs) was assessed using clone 22C3 (Dako). Clinical outcomes were correlated with molecular profile, including progression free survival (PFS), overall response rate (ORR), and overall survival (OS). Results: A total of 26 samples were included, median age was 67 years (r, 33–83) and 53.8% were men. Tobacco consumption was identified in all subjects (mean 34-year package). For first-line treatment 80.8% of patients received cisplatin or carboplatin plus gemcitabine. In terms of molecular profile, we identified a high prevalence of inactivating mutations in TP53 (61.5%), PIK3CA (34.6%), MLL2 (34.6%), KEAP1 (38.4%), and NOTCH1 (26.9%). PD-L1 expression ranged from negative, 1, 2–49, and ≥50% in 23.1, 38.5, 26.9, and 11.5%, respectively. Interestingly, the genetic alterations did not have an effect in PFS, OS or ORR in this study. However, PDL1 expression was higher among those who had mutations in TP53 (p = 0.037) and greater expression of PDL1 was related to PIK3CA alterations (p = 0.05). Conclusions: The genomic profile of SCC encompasses important genes including TP53, PIK3CA and KEAP1. TP53 mutations could be associated with PDL1 expression, generating hypothesis regarding specific treatment options.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fonc.2020.588932
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2234-943X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5314
dc.language.isoeng
dc.publisherFrontiers Media S.A.spa
dc.publisher.journalFrontiers in oncologyspa
dc.relation.ispartofseriesFrontiers in oncology, 2234-943X, Vol. 10, 2020spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fonc.2020.588932/full
dc.rightsAttribution 4.0 International*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-12-15
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsGenotypespa
dc.subject.keywordsLung cancerspa
dc.subject.keywordsPD-L1spa
dc.subject.keywordsSquamous cell carcinomaspa
dc.subject.keywordsTherapeutic targetspa
dc.titleGenotyping squamous cell lung carcinoma in Colombia (Geno1.1-CLICaP)spa
dc.title.translatedGenotyping squamous cell lung carcinoma in Colombia (Geno1.1-CLICaP)spa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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