Obtención y caracterización de nanopartículas mesoporosas a partir del método Sol-Gel cargadas con ibuprofeno

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dc.contributor.advisorJiménez Cruz, Ronald Andrés
dc.contributor.authorTriana Chambueta, Valentina
dc.date.accessioned2024-05-17T21:16:08Z
dc.date.available2024-05-17T21:16:08Z
dc.date.issued2024-05
dc.description.abstractEn respuesta a la creciente demanda de tecnologías innovadoras para el diagnóstico y tratamiento de enfermedades, el proyecto se enfocó en la síntesis y caracterización de nanopartículas de sílice mesoporosa mediante el método Sol-Gel y basadas en parámetros previamente estandarizados en la fase I del proyecto demostrando su potencial para la liberación prolongada de fármacos. Estas nanopartículas se purifican bajo dos condiciones, por medio de lavados y calcinación; además de probar tres cargas con Ibuprofeno como fármaco modelo a diferentes concentraciones (50, 100 y 150 mg). Se caracterizó mediante FIT-IR, SEM, XRD y DLS. De manera que se pudiera evaluar su eficiencia de encapsulación, se realizaron seis perfiles de liberación, mostrando que las nanopartículas cargadas luego de la calcinación liberan de manera controlada el fármaco y similar sin importar la concentración de la carga. Frente a las pruebas de reactividad biológica, estos prototipos presentan ligera actividad citotóxica y poca viabilidad celular respecto a la línea celular L929; lo que indica que a pesar de ser vehículos estables es necesario probarlo con diferentes fármacos y replantear parámetros (temperatura de calcinación o concentración de carga) que permitan una reactividad biológica sin actividad citotóxica.
dc.description.abstractenglishIn response to the growing demand for innovative technologies for the diagnosis and treatment of diseases, the project focused on the synthesis and characterization of mesoporous silica nanoparticles using the Sol-Gel method and based on parameters previously standardized in phase I of the project demonstrating its potential for sustained drug release. These nanoparticles are purified under two conditions, through washing and calcination; in addition to testing three loads with Ibuprofen as a model drug at different concentrations (50, 100 and 150 mg). It was characterized by FIT-IR, SEM, XRD and DLS. So that their encapsulation efficiency could be evaluated, six release profiles were carried out, showing that the loaded nanoparticles after calcination release the drug in a controlled manner and the like regardless of the concentration of the load. Faced with biological reactivity tests, these prototypes present slight cytotoxic activity and little cell viability compared to the L929 cell line; which indicates that despite being stable vehicles, it is necessary to test them with different drugs and rethink parameters (calcination temperature or charge concentration) that allow biological reactivity without cytotoxic activity.
dc.description.degreelevelPregradospa
dc.description.degreelevelQuímico Farmacéuticospa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad El Bosquespa
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/12145
dc.language.isoes
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.grantorUniversidad El Bosquespa
dc.publisher.programQuímica Farmacéuticaspa
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dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacionalen
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.localAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectNanopartículas
dc.subjectSíntesis
dc.subjectSílice
dc.subjectIbuprofeno
dc.subjectCarga
dc.subjectPurificación
dc.subject.ddc615.19
dc.subject.keywordsNanoparticles
dc.subject.keywordsSynthesis
dc.subject.keywordsSilica
dc.subject.keywordsIbuprofen
dc.subject.keywordsLoad
dc.subject.keywordsPurification
dc.titleObtención y caracterización de nanopartículas mesoporosas a partir del método Sol-Gel cargadas con ibuprofeno
dc.title.translatedObtaining and characterization of mesoporous nanoparticles from the Sol-Gel method loaded with ibuprofen
dc.type.coarhttps://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttps://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
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