Shape follows function: gastrointestinal signals for enterococcal colonization

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Fecha

2019

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Publicado en

Trends in molecular medicine, 1471-499X, Vol. 25, Nro. 6, 2019, p. 464-466

Publicado por

Elsevier

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Abstract

Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance

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Keywords

Antibiotic resistance, Daptomycin, Enterococcus

Temáticas

Tracto gastrointestinal
Farmacorresistencia microbiana
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