Delay in starting radiotherapy due to neoadjuvant therapy does not worsen survival in unresected glioblastoma patients

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dc.contributor.authorBalaña, Carmen
dc.contributor.authorEstival, A.
dc.contributor.authorTeruel, I.
dc.contributor.authorHardy-Werbin, M.
dc.contributor.authorSepulveda, J.
dc.contributor.authorPineda, E.
dc.contributor.authorMartinez-García, M.
dc.contributor.authorGallego, O.
dc.contributor.authorLuque, R.
dc.contributor.authorGil-Gil, M.
dc.contributor.authorMesia, C.
dc.contributor.authorDel Barco, S.
dc.contributor.authorHerrero, A.
dc.contributor.authorBerrocal, A.
dc.contributor.authorPerez-Segura, P.
dc.contributor.authorDe las Penas, R.
dc.contributor.authorMarruecos, J.
dc.contributor.authorFuentes, R.
dc.contributor.authorReynes, G.
dc.contributor.authorVelarde, J. M.
dc.contributor.authorCardona-Mendoza, Andrés Felipe
dc.contributor.authorVerger, E.
dc.contributor.authorPanciroli, C.
dc.contributor.authorVillà, S.
dc.contributor.orcidCardona-Mendoza, Andrés Felipe [0000-0002-6697-5471]
dc.date.accessioned2020-05-18T11:44:52Z
dc.date.available2020-05-18T11:44:52Z
dc.date.issued2018
dc.description.abstractenglishPurpose We retrospectively examined the potential effect on overall survival (OS) of delaying radiotherapy to administer neoadjuvant therapy in unresected glioblastoma patients. Patients and methods We compared OS in 119 patients receiving neoadjuvant therapy followed by standard treatment (NA group) and 96 patients receiving standard treatment without neoadjuvant therapy (NoNA group). The MaxStat package of R identified the optimal cut-off point for waiting time to radiotherapy. Results OS was similar in the NA and NoNA groups. Median waiting time to radiotherapy after surgery was 13 weeks for the NA group and 4.2 weeks for the NoNA group. The longest OS was attained by patients who started radiotherapy after 12 weeks and the shortest by patients who started radiotherapy within 4 weeks (12.3 vs 6.6 months) (P = 0.05). OS was 6.6 months for patients who started radiotherapy before the optimal cutoff of 6.43 weeks and 19.1 months for those who started after this time (P = 0.005). Patients who completed radiotherapy had longer OS than those who did not, in all 215 patients and in the NA and NoNA groups (P = 0.000). In several multivariate analyses, completing radiotherapy was a universally favorable prognostic factor, while neoadjuvant therapy was never identified as a negative prognostic factor. Conclusion In our series of unresected patients receiving neoadjuvant treatment, in spite of the delay in starting radiotherapy, OS was not inferior to that of a similar group of patients with no delay in starting radiotherapy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12094-018-1883-7
dc.identifier.issn1699-048X
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2947
dc.language.isoeng
dc.publisher.journalClinical and Translational Oncology volumespa
dc.relation.ispartofseriesClinical and Translational Oncology volume, 1699-048X, Vol 20, Num 12, 2018, pag 1529-1537spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs12094-018-1883-7
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsTerapia neoadyuvantespa
dc.subject.decsGlioblastoma -- Tratamientospa
dc.subject.decsNeoplasias neuroepitelialesspa
dc.subject.keywordsGlioblastomaspa
dc.subject.keywordsNeoadjuvantspa
dc.subject.keywordsUnresectedspa
dc.subject.keywordsRadiotherapy delayspa
dc.subject.keywordsMGMTspa
dc.subject.keywordsPrognosisspa
dc.subject.keywordsGlioblastomaspa
dc.subject.keywordsNeoadjuvant therapyspa
dc.subject.keywordsWaiting time to radiotherapyspa
dc.subject.keywordsOverall survivalspa
dc.titleDelay in starting radiotherapy due to neoadjuvant therapy does not worsen survival in unresected glioblastoma patientsspa
dc.title.translatedDelay in starting radiotherapy due to neoadjuvant therapy does not worsen survival in unresected glioblastoma patientsspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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