Anti-proliferative bioactivity against HT-29 colon cancer cells of a withanolides-rich extract from golden berry (Physalis peruviana L.) calyx investigated by Foodomics

Vista sencilla de ítem
dc.contributor.authorBallesteros Vivas, Diego
dc.contributor.authorAlvarez Rivera, Gerardo
dc.contributor.authorLeón, Carlos
dc.contributor.authorMorantes, Sandra Johanna
dc.contributor.authorIbánez, Elena
dc.contributor.authorParada Alfonso, Fabián
dc.contributor.authorCifuentes, Alejandro
dc.contributor.authorValdés, Alberto
dc.date.accessioned2020-03-26T23:05:23Z
dc.date.available2020-03-26T23:05:23Z
dc.date.issued2019
dc.description.abstractenglishA comprehensive Foodomics study was carried out in this work to investigate the changes induced at gene and metabolite expression levels on HT29 colon cancer cell lines upon treatment with a bioactives-enriched extract from goldenberry calyx. As a result of the proposed multi-omics approach, the tested extract induced transcriptional activation of pro-apoptotic genes, and altered the expression of several genes related to the oxidative stress response in treated cancer cells. Metabolomics data confirm altered cellular redox homeostasis, providing additional evidence to transcriptomic results. Foodomics data integration also revealed alteration on relevant metabolic processes, suggesting inactivation of aminoacyl tRNA charging pathway, dysfunction on carnitine shuttle and beta-oxidation of fatty acids, and pyrimidine ribonucleotide interconversion impairment. These observations are in line with functional analysis and anti-proliferative activity results, where the viability of HT-29 colon cancer cells was notably reduced after 48 h treatment without affecting the viability of normal human colon fibroblast cells.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jff.2019.103567
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1756-4646
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2165
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalJournal of Functional Foodsspa
dc.relation.ispartofseriesJournal of Functional Foods, 1756-4646, Vol 63, 2019spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S1756464619304918
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf23
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsMetabolómicaspa
dc.subject.decsNeoplasias colorrectalesspa
dc.subject.decsFitoquímicosspa
dc.subject.keywordsGoldenberry calyxspa
dc.subject.keywordsColon cancerspa
dc.subject.keywordsAnti-proliferative activityspa
dc.subject.keywordsMetabolomicsspa
dc.subject.keywordsTranscriptomicsspa
dc.subject.keywordsFoodomicsspa
dc.titleAnti-proliferative bioactivity against HT-29 colon cancer cells of a withanolides-rich extract from golden berry (Physalis peruviana L.) calyx investigated by Foodomicsspa
dc.title.translatedAnti-proliferative bioactivity against HT-29 colon cancer cells of a withanolides-rich extract from golden berry (Physalis peruviana L.) calyx investigated by Foodomics
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Ballesteros-Vivas_Diego_2019.pdf
Tamaño:
4.88 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos