Effects of leukocyte–platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review

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dc.contributor.authorDragonas, Panagiotis
dc.contributor.authorKatsaros, T
dc.contributor.authorAvila‐ortiz, Gustavo
dc.contributor.authorChambrone, Leandro
dc.contributor.authorSchiavo, Julie H.
dc.contributor.authorPalaiologou, A. Archontia
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.date.accessioned2020-03-14T15:42:43Z
dc.date.available2020-03-14T15:42:43Z
dc.date.issued2019
dc.description.abstractenglishThis systematic review aimed to assess the effects of leukocyte–platelet-rich fibrin (L-PRF) on bone regeneration, soft tissue healing, and postoperativecomplications in patients undergoing ridge preservation, ridge augmentation, andmaxillary sinus augmentation procedures. A comprehensive literature search wasconducted by two independent reviewers. Only randomized and non-randomizedcontrolled clinical trials were selected. Outcome data were extracted and criticallyanalyzed. A total of 17 articles were included in the qualitative synthesis. The use ofL-PRF in extraction sockets was associated with a modest beneficial effect bydecreasing alveolar ridge remodeling and postoperative pain when compared tonatural healing. In contrast, the use of L-PRF in maxillary sinus augmentationprocedures was not associated with more favorable outcomes, and its use in ridgeaugmentation procedures could not be assessed adequately as it was reported in onlyone study. No meta-analysis could be conducted due to the heterogeneity of theselected studies. The limited evidence on the effects of L-PRF in intraoral bonegrafting procedures highlights the need for further research to fully assess its clinicalindications, with an emphasis on the application of standardized protocols for thepreparation of this autologous product.Key words: leukocytes; platelet-rich fibrin;maxillary sinus; alveolar ridge augmentation;sinus floor augmentation; tooth extraction;growth factors.Accepted for publication 7 June 2018Available online 7 July 2018Leukocyte–platelet-rich fibrin (L-PRF)was initially introduced by Dr JosephChoukroun in the early 2000s as a thera-peutic adjuvant to enhance wound healingand tissue regeneration following intraoralsurgical procedures1. L-PRF is considereda second-generation platelet concentrate,characterized by a simplified preparationmethod without any biochemical manipu-lation or exogenous additives to the bloodsample2. For its preparation, venous bloodis harvested and centrifuged in a tubeInt. J. Oral Maxillofac. Surg. 2019; 48: 250–262https://doi.org/10.1016/j.ijom.2018.06.003, available online at https://www.sciencedirect.com0901-5027/020250 + 013 ã 2018 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijom.2018.06.003
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0901-5027
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2050
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalInternational Journal of Oral and Maxillofacial Surgeryspa
dc.relation.ispartofseriesInternational Journal of Oral and Maxillofacial Surgery, 0901-5027, Vol. 48, Num. 2, 2019, p.250-262spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0901502718302169?via%3Dihub
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf123
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsPlasma rico en plaquetasspa
dc.subject.decsSenos paranasalesspa
dc.subject.decsProcedimientos quirúrgicos oralesspa
dc.subject.keywordsPlatelet-rich fibrinspa
dc.subject.keywordsMaxillary sinusspa
dc.subject.keywordsAlveolar ridge augmentationspa
dc.subject.keywordsSinus floor augmentationspa
dc.subject.keywordsTooth extractionspa
dc.subject.keywordsGrowth factorsspa
dc.subject.keywordsLeukocytesspa
dc.titleEffects of leukocyte–platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic reviewspa
dc.title.translatedEffects of leukocyte–platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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