A systematic review and meta-analysis on effect of beta-blockers in severe traumatic brain injury

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dc.contributor.authorFlorez Perdomo, William A.
dc.contributor.authorLaiseca Torres, Edgar Felipe
dc.contributor.authorSerrato, Sergio a
dc.contributor.authorJanjua, Tariq
dc.contributor.authorJoaquim, Andrei F.
dc.contributor.authorMoscote Salazar, Luis Rafael
dc.date.accessioned2021-05-20T16:22:59Z
dc.date.available2021-05-20T16:22:59Z
dc.date.issued2021-01-22
dc.description.abstractenglishObjectives: Systematically review the medical literature for the impact of beta-blockers on mortality and functional capacity in patients who suffered severe traumatic brain injury. Data Sources: The search included MEDLINE, EMBASE, and Ovid Evidence-Based Medicine, clinical trial registries, and bibliographies. Study Selection: All articles that reported outcome in TBI patients treated with beta-blockers. Data Extraction: Publication year, number of patients, outcome and follow-up. We performed a meta-analysis for each variable for which there were sufficient data to estimate mean differences. Data Synthesis: 12 studies were included, which involved retrospectively and prospectively collected data on 14,057 patients. The treatment with beta-blockers was associated with a reduction in mortality in patients who were treated with beta-blockers compared to the control group (OR 0.40, 95% CI 0.30–0.54p = <0.00001), with acceptable heterogeneity between studies (I2 = 65% p = 0.00008). Beta-blocker therapy decreases the risk of negative neurological and functional outcomes (OR 0.59, 95% CI 0.38–0.92 p = <0.00001), a very high statistical heterogeneity between the included studies (I2 = 80% p = 0.00004), being able to influence the results. An increase in favorable neurological and functional outcomes is shown (OR 1.19, 95% CI 1.07–1.31 p = 0.001) with acceptable heterogeneity (I2 = 52% p = 0.08) Conclusions: The beta-blockers therapy is associated with significantly improves outcome in patients with TBI. Treatment with beta-blockers in patients with TBI is a promising frontier in neurotrauma. Abbreviations:CI: confidence interval; BB: Beta-Blockers; OR = odds ratio; TBI: Traumatic Brain Injury SD: Standard deviation; SNS: Sympathetic nervous systemeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/01616412.2020.1866385
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1743-1328
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5884
dc.language.isoeng
dc.publisherTaylor & Francis Groupspa
dc.publisher.journalNeurological Researchspa
dc.relation.ispartofseriesNeurological Research, 1743-1328, 2021spa
dc.relation.urihttps://www.tandfonline.com/doi/full/10.1080/01616412.2020.1866385
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.subject.keywordsBeta-(β)-blockers improve outcomes after acute traumatic brain injury (TBI)spa
dc.titleA systematic review and meta-analysis on effect of beta-blockers in severe traumatic brain injuryspa
dc.title.translatedA systematic review and meta-analysis on effect of beta-blockers in severe traumatic brain injuryspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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