Bronchiolitis phenotypes identified by latent class analysis may influence the occurrence of respiratory sequelae

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dc.contributor.authorPetrarca, Laura
dc.contributor.authorFrassanito, Antonella
dc.contributor.authorRodríguez-Martínez, Carlos E.
dc.contributor.authorMancino, Enrica
dc.contributor.authorArima, Serena
dc.contributor.orcidNenna, Raffaella [https://orcid.org/0000-0001-8880-3462]
dc.contributor.orcidDi Mattia, Greta [https://orcid.org/0000-0001-5621-2713]
dc.contributor.orcidCastro-Rodriguez, Jose A. [https://orcid.org/0000-0002-0708-4281]
dc.contributor.orcidScagnolari, Carolina [https://orcid.org/0000-0003-1044-1478]
dc.contributor.orcidPierangeli, Alessandra [https://orcid.org/0000-0003-0633-360X]
dc.contributor.orcidMidulla, Fabio [https://orcid.org/0000-0001-7476-5266]
dc.date.accessioned2022-03-02T20:40:40Z
dc.date.available2022-03-02T20:40:40Z
dc.date.issued2021
dc.description.abstractenglishBackground The heterogeneity of bronchiolitis may imply or reflect a different predisposition to respiratory sequelae. Objective Our aim was to investigate whether, among infants hospitalized with bronchiolitis, different clinical profiles extracted by latent class analysis (LCA) are associated with different risks of wheezing. Methods Over 15 consecutive epidemic seasons (2004–2019), we prospectively enrolled infants <1 year hospitalized for the first episode of bronchiolitis in a single tertiary hospital. A detailed clinical questionnaire was filled for each infant. LCA was applied to differentiate bronchiolitis phenotypes, and after hospital discharge, a phone interview was performed annually to record the presence of wheezing episodes. Adjusted multivariate regression analyses were run to investigate the risk of wheezing during 7 years follow-up according to clinical phenotypes. Results LCA performed on 1312 infants resulted in a three-class model. Profile 1 (65.5%): moderate bronchiolitis; Profile 2 (6.1%): severe bronchiolitis; and Profile 3(28.4%): bronchiolitis infants with high eosinophils blood count. At 1 year of follow up, about 50% of children presented wheezing in each profile. Compared to Profile 1, the adjusted odds ratio (OR) of having wheezing episodes was significantly higher in Profile 2 at 2, 3, and 4 years of follow-up. At 7 years, Profile 3 had an adjusted OR = 2.58, higher than Profile 2 (adjusted OR = 2.29). Conclusions LCA clearly identified a “moderate”, “severe,” and “high eosinophils blood count” bronchiolitis. During the first 4 years after bronchiolitis, the “severe” profile showed the higher risk of wheezing, but after 7 years this risk seems higher in the “high eosinophils blood count” groupeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/ppul.25799
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn8755-6863
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/7062
dc.language.isoeng
dc.publisherJohn Wiley and Sons Incspa
dc.publisher.journalPediatric Pulmonologyspa
dc.relation.ispartofseriesPediatric Pulmonology, 8755-6863, 2021spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/ppul.25799?af=R
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.localAcceso abiertospa
dc.titleBronchiolitis phenotypes identified by latent class analysis may influence the occurrence of respiratory sequelaespa
dc.title.translatedBronchiolitis phenotypes identified by latent class analysis may influence the occurrence of respiratory sequelaespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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