Postbiotics for preventing and treating common infectious diseases in children: A systematic review

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dc.contributor.authorMalagón-Rojas, Jeadran N.
dc.contributor.authorMantziari, Anastasia
dc.contributor.authorSalminen, Seppo
dc.contributor.authorSzajewska, Hania
dc.date.accessioned2020-03-09T15:57:32Z
dc.date.available2020-03-09T15:57:32Z
dc.date.issued2020
dc.description.abstractenglishPostbiotics have recently been tentatively defined as bioactive compounds produced during a fermentation process (including microbial cells, cell constituents and metabolites) that supports health and/or wellbeing. Postbiotics are currently available in some infant formulas and fermented foods. We systematically reviewed evidence on postbiotics for preventing and treating common infectious diseases among children younger than 5 years. The PubMed, Embase, SpringerLink, and ScienceDirect databases were searched up to March 2019 for randomized controlled trials (RCTs) comparing postbiotics with placebo or no intervention. Seven RCTs involving 1740 children met the inclusion criteria. For therapeutic trials, supplementation with heat-killed Lactobacillus acidophilus LB reduced the duration of diarrhea (4 RCTs, n = 224, mean difference, MD, −20.31 h, 95% CI −27.06 to −13.57). For preventive trials, the pooled results from two RCTs (n = 537) showed that heat‐inactivated L. paracasei CBA L74 versus placebo reduced the risk of diarrhea (relative risk, RR, 0.51, 95% CI 0.37–0.71), pharyngitis (RR 0.31, 95% CI 0.12–0.83) and laryngitis (RR 0.44, 95% CI 0.29–0.67). There is limited evidence to recommend the use of specific postbiotics for treating pediatric diarrhea and preventing common infectious diseases among children. Further studies are necessary to determine the effects of different postbioticseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/nu12020389
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2072-6643
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2023
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)spa
dc.publisher.journalNutrientsspa
dc.relation.ispartofseriesNutrients, 2072-6643, Vol. 12, Nro. 2, 2020spa
dc.relation.urihttps://www.mdpi.com/2072-6643/12/2/389
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf201
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsSalud públicaspa
dc.subject.decsPrevención de enfermedadesspa
dc.subject.decsPlacebosspa
dc.subject.keywordsChildrenspa
dc.subject.keywordsCommon infectious diseasesspa
dc.subject.keywordsPostbioticsspa
dc.titlePostbiotics for preventing and treating common infectious diseases in children: A systematic reviewspa
dc.title.translatedPostbiotics for preventing and treating common infectious diseases in children: A systematic review
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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