Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review

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dc.contributor.authorColorado Osorio, Catalina
dc.contributor.authorVargas Escobar, Lina María
dc.contributor.authorGonzález Carrera, María Clara
dc.contributor.authorGamboa, Luis Fernamdo
dc.contributor.authorChambrone, Leandro
dc.contributor.orcidGonzález Carrera, María Clara [0000-0003-4572-1453]
dc.contributor.orcidVargas Escobar, Lina María [0000-0003-0052-5467]
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.contributor.orcidColorado Osorio, Catalina [0000-0001-9275-7390]
dc.contributor.orcidColorado Osorio, Catalina [0000-0001-9275-7390]
dc.date.accessioned2020-09-16T21:47:08Z
dc.date.available2020-09-16T21:47:08Z
dc.description.abstractenglishObjective: To assess clinical studies that compare synthetic or enriched natural materials to autologous osseous grafts among individuals with cleft lip and palate to determine which would be the substitute to autologous bone graft for alveolar cleft repair in humans. Materials and methods: Randomized and controlled clinical trials on alveolar clefts treated with synthetic bone substitutes and autogenous bone grafts combined with osteoinductive factors compared with autogenous bone grafts alone (with ≥4-month follow-up and reporting clinical/radiographic data) were considered eligible. MEDLINE, EMBASE, and Central databases were searched for articles published until February 2020. Results: Of 73 eligible articles, 15 were included. Some inductive factors along with iliac crest bone decreased bone reabsorption, preserved the generated bone height/width, and reduced the required autologous bone graft volume. Bone morphogenetic protein (BMP2) as an autologous bone graft substitute, demonstrated satisfactory alveolar defect healing, by avoiding autograft use. Many materials did not yield better outcomes than did autologous grafts; however, hydroxyapatite and collagen complex, hydroxyapatite agarose composite gel, acellular dermal matrix film, fibrin glue, platelet-rich plasma, and deproteinized bovine bone showed similar bone healing outcomes, being an alternative alveolar defect treatment. Conclusions: BMP2, as an osteoinductive factor along with a synthetic matrix, yields satisfactory bone healing and avoids the need for autologous bone grafts. However, high-quality RCTs are necessary to determine the most effective and safe concentration and protocol of BMP2 utilization as a substitute for the autologous iliac crest bone grafting.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2020.e04646
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2405-8440
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4109
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalHeliyonspa
dc.relation.ispartofseriesHeliyon, 2405-8440, Vol. 6, Nro. 9, 2020spa
dc.relation.urihttps://www.cell.com/heliyon/fulltext/S2405-8440(20)31490-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844020314900%3Fshowall%3Dtrue
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-08-03
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.keywordsAlveolar bone graftingspa
dc.subject.keywordsAlveolar cleftspa
dc.subject.keywordsBiomedical engineeringspa
dc.subject.keywordsBiotechnologyspa
dc.subject.keywordsCleft lipspa
dc.subject.keywordsCleft lip repairspa
dc.subject.keywordsDental surgeryspa
dc.titleEvaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic reviewspa
dc.title.translatedEvaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic reviewspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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