Autoantibodies and gastrointestinal symptoms in colombian children with Juvenile idiopathic arthritis

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dc.contributor.authorGonzalez, Tatiana
dc.contributor.authorMalagon, Clara
dc.contributor.authorGuarnizo, Pilar
dc.contributor.authorMosquera, Angela C.
dc.contributor.authorChila-Moreno, Lorena
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.date.accessioned2020-05-15T17:57:40Z
dc.date.available2020-05-15T17:57:40Z
dc.date.issued2018
dc.description.abstractenglishBackground: Juvenile Idiopathic Arthritis (JIA) is the most common inflammatory joint disease in children. JIA and autoimmune inflammatory Gastrointestinal (GI) diseases share common etiologic mechanisms, including genetic predisposition and environmental influences. Objective: To Investigate association between gastrointestinal, rheumatologic clinical variables and the presence of autoantibodies in patients with JIA in treatment. Methodology: In a cross-sectional study of patients with JIA according to diagnostic criteria and the ILAR classification. GI symptoms and autoantibody expression were evaluated with respect to their association with JIA clinical variables. Anti-Saccharomyces Cerevisiae IgG/IgA (ASCA), 6 antigen associated with anti polymorphonuclear neutrophil (ANCA), anti Transglutaminase (tTG) IgG/IgA, anti deaminated gliadin peptide (DGP) IgG/IgA autoantibodies, ANAS and IgA were measured in all patients. The association between clinical variables and auto-antibodies were evaluated using the Fisher test with significant value of p <0.05. The study was approved by the ethics committee of the all institutions. Results: Samples were collected from ninety-seven patients, 63% of whom were female. The average age was 14 years. The JIA subtype associated with the most common GI symptoms was enthesitis- related arthritis. Of these patients, 44.3% and 14% reported abdominal pain and diarrhea, respectively. Anti-DPG and anti-tTG antibodies were found in 9.28% and 7.22%, respectively and 11.34% were positive for p-ANCA, and 2% were positive for ASCA. Conclusion: GI symptoms and autoantibodies associated with inflammation of the GI mucosa were detected in JIA patients but were not associated with autoantibodies or clinical variables. However, it is the monitoring of these patients diagnosis is important.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1573397114666180108110429
dc.identifier.issn1573-3971
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2843
dc.language.isoeng
dc.publisherBentham Sciencespa
dc.publisher.journalCurrent Rheumatology Reviewsspa
dc.relation.ispartofseriesCurrent Rheumatology Reviews, 1573-3971, Vol 14, Num 2, 2018, pag 163-171spa
dc.relation.urihttps://www.eurekaselect.com/158867/article
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.armarcColombiaspa
dc.subject.decsAnticuerposspa
dc.subject.decsArtritisspa
dc.subject.decsTracto gastrointestinalspa
dc.subject.decsNiñosspa
dc.titleAutoantibodies and gastrointestinal symptoms in colombian children with Juvenile idiopathic arthritisspa
dc.title.translatedAutoantibodies and gastrointestinal symptoms in colombian children with Juvenile idiopathic arthritisspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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