Outlining the ancestry landscape of Colombian admixed populations

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dc.contributor.authorOssa, Humberto
dc.contributor.authorAquino Machado, Juliana
dc.contributor.authorPereira, Rui
dc.contributor.authorIbarra, Adriana
dc.contributor.authorOssa, Rafael H.
dc.contributor.authorPérez, Luz Adriana
dc.contributor.authorGranda, Juan David
dc.contributor.authorLattig, María Claudia
dc.contributor.authorGroot, Helena
dc.contributor.authorFagundes de Carvalho, Elizeu
dc.contributor.authorGusmão, Leonor
dc.date.accessioned2020-04-20T00:55:09Z
dc.date.available2020-04-20T00:55:09Z
dc.date.issued2016
dc.description.abstractenglishThe ancestry of the Colombian population comprises a large number of well differentiated Native communities belonging to diverse linguistic groups. In the late fifteenth century, a process of admixture was initiated with the arrival of the Europeans, and several years later, Africans also became part of the Colombian population. Therefore, the genepool of the current Colombian population results from the admixture of Native Americans, Europeans and Africans. This admixture occurred differently in each region of the country, producing a clearly stratified population. Considering the importance of population substructure in both clinical and forensic genetics, we sought to investigate and compare patterns of genetic ancestry in Colombia by studying samples from Native and non-Native populations living in its 5 continental regions: the Andes, Caribe, Amazonia, Orinoquía, and Pacific regions. For this purpose, 46 AIM-Indels were genotyped in 761 non-related individuals from current populations. Previously published genotype data from 214 Colombian Natives from five communities were used for population comparisons. Significant differences were observed between Native and non-Native populations, among non-Native populations from different regions and among Native populations from different ethnic groups. The Pacific was the region with the highest African ancestry, Amazonia harboured the highest Native ancestry and the Andean and Orinoquían regions showed the highest proportion of European ancestry. The Andean region was further sub-divided into 6 sub-regions: North East, Central West, Central East, West, South West and South East. Among these regions, the South West region showed a significantly lower European admixture than the other regions. Hardy-Weinberg equilibrium and variance values of ancestry among individuals within populations showed a potential stratification of the Pacific population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0164414
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1932-6203
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2303
dc.language.isoeng
dc.publisherPublic Library of Sciencespa
dc.publisher.journalPlos onespa
dc.relation.ispartofseriesPlos one, 1932-6203. Vol. 11, Nro. 10, 2016spa
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164414
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf241
dc.rights.creativecommons2016
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsHibridación genéticaspa
dc.subject.decsRelaciones racialesspa
dc.subject.decsHistoria del siglo XV / Colombiaspa
dc.titleOutlining the ancestry landscape of Colombian admixed populationsspa
dc.title.translatedOutlining the ancestry landscape of Colombian admixed populations
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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Ossa H., Aquino J., Pereira R., Ibarra A., Ossa R.H., Pérez L.A., Granda J.D., Lattig M.C., Groot H., De Carvalho E.F., Gusmão L._2016.pdf
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