An epidemiological and molecular study regarding the spread of vancomycinresistant Enterococcus faecium in a teaching hospital in Bogotá, Colombia 2016

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dc.contributor.authorCorredor, Nancy Carolina
dc.contributor.authorLópez, Carolina
dc.contributor.authorAguilera, Paula Andrea
dc.contributor.authorRodríguez-Leguizamón, Giovanni
dc.contributor.authorLeal, Aura Lucía
dc.contributor.authorOvalle-Guerro, María Victoria
dc.contributor.authorPardo-Oviedo, Juan Mauricio
dc.contributor.authorPatarroyo, Manuel Alfonso
dc.contributor.authorPrieto, Lina María
dc.contributor.authorChica, Claudia Elena
dc.date.accessioned2019-07-29T13:17:09Z
dc.date.available2019-07-29T13:17:09Z
dc.date.issued2019
dc.description.abstractenglishBackground Enterococcus faecium is ranked worldwide as one of the top ten pathogens identified in healthcare-associated infections (HAI) and is classified as one of the high priority pathogens for research and development of new antibiotics worldwide. Due to molecular biology techniques’ higher costs, the approach for identifying and controlling infectious diseases in developing countries has been based on clinical and epidemiological perspectives. Nevertheless, after an abrupt vancomycin-resistant Enterococcus faecium dissemination in the Méderi teaching hospital, ending up in an outbreak, further measures needed to be taken into consideration. The present study describes the vancomycin-resistant Enterococcus faecium pattern within Colombian’s largest installed-bed capacity hospital in 2016. Methods Thirty-three vancomycin-resistant Enterococcus faecium isolates were recovered during a 5-month period in 2016. Multilocus variable-number tandem-repeat analysis was used for molecular typing to determine clonality amongst strains. A modified time-place-sequence algorithm was used to trace VREfm spread patterns during the outbreak period and estimate transmission routes. Results Four clonal profiles were identified. Chronological clonal profile follow-up suggested a transitional spread from profile “A” to profile “B”, returning to a higher prevalence of “A” by the end of the study. Antibiotic susceptibility indicated high-level vancomycin-resistance in most isolates frequently matching vanA gene identification.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12879-019-3877-7
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1471-2334
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/1569
dc.language.isoeng
dc.publisherBiomed Centralspa
dc.publisher.journalBMC Infectious Diseasesspa
dc.relation.ispartofseriesBMC Infectious Diseases, 1471-2334, Vol.19, Nro.258, 2019 p. 1-11spa
dc.relation.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3877-7
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf434
dc.rights.creativecommons2019
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectEnterococcus faecium resistente a la vancomicinaspa
dc.subjectVigilancia de brotesspa
dc.subjectResistencia antimicrobianaspa
dc.subject.decsResistencia a la vancomicinaspa
dc.subject.decsBrotes de enfermedadesspa
dc.subject.decsVirologíaspa
dc.subject.keywordsVancomycin-resistant Enterococcus faeciumspa
dc.subject.keywordsOutbreak surveillancespa
dc.subject.keywordsAntimicrobial resistancespa
dc.titleAn epidemiological and molecular study regarding the spread of vancomycinresistant Enterococcus faecium in a teaching hospital in Bogotá, Colombia 2016spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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