Presentation and outcomes of Kawasaki disease in Latin American infants younger than 6 months of age: a multinational multicenter study of the REKAMLATINA network

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dc.contributor.authorMoreno, Elizabeth
dc.contributor.authorGarcía, Sara Diana
dc.contributor.authorBainto, Emelia V.
dc.contributor.authorSalgado, Andrea P.
dc.contributor.authorParish, Austin
dc.contributor.authorRosellini, Benjamin D.
dc.contributor.authorUlloa-Gutierrez, Rolando
dc.contributor.authorGarrido, Luis Martin
dc.contributor.authorDueńas, Lourdes
dc.contributor.authorEstripeaut, Dora
dc.contributor.authorLuciani, Kathia
dc.contributor.authorRodríguez-Quiroz, Francisco J.
dc.contributor.authorDel Aguila, Olguita
dc.contributor.authorCamacho Moreno, German
dc.contributor.authorGómez Alba, Virgen
dc.contributor.authorViviani, Tamara
dc.contributor.authorÁlvarez-Olmos, Martha I
dc.contributor.authorde Souza Marques, Heloisa Helena
dc.contributor.authorFaugier-Fuentes, Enrique
dc.contributor.authorSaltigeral-Simental, Patricia
dc.contributor.authorLópez Medina, Eduardo
dc.contributor.authorMiño-León, Greta
dc.contributor.authorBeltrán, Sandra
dc.contributor.authorMartínez-Arellano, Lucila
dc.contributor.authorPírez, María Catalina
dc.contributor.authorCofré, Fernanda
dc.contributor.authorTremoulet, Adriana H.
dc.contributor.authorREKAMLATINA-2 Study Group Investigators
dc.date.accessioned2020-08-10T18:58:31Z
dc.date.available2020-08-10T18:58:31Z
dc.description.abstractenglishObjective: To characterize the clinical presentation and outcomes of Kawasaki disease (KD) in infants <6 months of age as compared to those ≥6 months in Latin America. Methods: We evaluated 36 infants <6 months old and 940 infants ≥6 months old diagnosed with KD in Latin America. We compared differences in laboratory data, clinical presentation, treatment response, and coronary artery outcomes between the two cohorts. Results: The majority (78.1%) of infants and children ≥6 months of age were initially diagnosed with KD, as compared to only 38.2% of infants <6 months. Clinical features of KD were more commonly observed in the older cohort: oral changes (92 vs. 75%, P = 0.0023), extremity changes (74.6 vs. 57.1%, P = 0.029), and cervical lymphadenopathy (67.6 vs. 37.1%, P = 0.0004). Whether treated in the first 10 days of illness or after the 10th day, infants <6 months were at greater risk of developing a coronary artery aneurysm compared to KD patients ≥6 months treated at the same point in the course of illness [ ≤ 10 days (53.8 vs. 9.4%, P = 0.00012); >10 days (50 vs. 7.4%, P = 0.043)]. Conclusion: Our data show that despite treatment in the first 10 days of illness, infants <6 months of age in Latin America have a higher risk of developing a coronary artery aneurysm. Delay in the diagnosis leads to larger coronary artery aneurysms disproportionately in these infants. Thus, suspicion for KD should be high in this vulnerable population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fped.2020.00384
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2296-2360
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3744
dc.language.isoeng
dc.publisherFrontiers Media S.A.spa
dc.publisher.journalFrontiers in pediatricsspa
dc.relation.ispartofseriesFrontiers in pediatrics. 2296-2360, Vol. 8, 2020spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fped.2020.00384/full
dc.rightsAttribution 4.0 International*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-07-16
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsCoronary artery abnormalitiesspa
dc.subject.keywordsDelayed diagnosisspa
dc.subject.keywordsInfantsspa
dc.subject.keywordsKawasaki diseasespa
dc.titlePresentation and outcomes of Kawasaki disease in Latin American infants younger than 6 months of age: a multinational multicenter study of the REKAMLATINA networkspa
dc.title.translatedPresentation and outcomes of Kawasaki disease in Latin American infants younger than 6 months of age: a multinational multicenter study of the REKAMLATINA networkspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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