Evolving resistance among gram-positive pathogens

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dc.contributor.authorMunita, Jose M.
dc.contributor.authorBayer, Arnold S.
dc.contributor.authorArias, Cesar A.
dc.date.accessioned2020-08-06T20:19:47Z
dc.date.available2020-08-06T20:19:47Z
dc.date.issued2015
dc.description.abstractenglishAntimicrobial therapy is a key component of modern medical practice and a cornerstone for the development of complex clinical interventions in critically ill patients. Unfortunately, the increasing problem of antimicrobial resistance is now recognized as a major public health threat jeopardizing the care of thousands of patients worldwide. Gram-positive pathogens exhibit an immense genetic repertoire to adapt and develop resistance to virtually all antimicrobials clinically available. As more molecules become available to treat resistant gram-positive infections, resistance emerges as an evolutionary response. Thus, antimicrobial resistance has to be envisaged as an evolving phenomenon that demands constant surveillance and continuous efforts to identify emerging mechanisms of resistance to optimize the use of antibiotics and create strategies to circumvent this problem. Here, we will provide a broad perspective on the clinical aspects of antibiotic resistance in relevant gram-positive pathogens with emphasis on the mechanistic strategies used by these organisms to avoid being killed by commonly used antimicrobial agents.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/cid/civ523
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1537-6591
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3725
dc.language.isoeng
dc.publisherOxford University Pressspa
dc.publisher.journalClinical Infectious Diseasesspa
dc.relation.ispartofseriesClinical Infectious Diseases, 1537-6591, Vol 61, Nro. supp 2, 2015, p. S48–S57spa
dc.relation.urihttps://academic.oup.com/cid/article/61/suppl_2/S48/396732
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2015-08-24
dc.rights.localAcceso abiertospa
dc.subject.keywordsAntimicrobial resistancespa
dc.subject.keywordsMultidrug-resistantspa
dc.subject.keywordsMethicillin-resistantspa
dc.subject.keywordsVancomycin-resistantspa
dc.subject.keywordsPenicillin-resistantspa
dc.titleEvolving resistance among gram-positive pathogensspa
dc.title.translatedEvolving resistance among gram-positive pathogensspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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