Mechanisms of antibiotic resistance in enterococci

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dc.contributor.authorMiller, William R.
dc.contributor.authorMunita, Jose M.
dc.contributor.authorArias, Cesar A.
dc.date.accessioned2020-10-30T20:08:12Z
dc.date.available2020-10-30T20:08:12Z
dc.date.issued2014
dc.description.abstractenglishMultidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1586%2F14787210.2014.956092
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1744-8336
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4604
dc.language.isoeng
dc.publisherTaylor & Francisspa
dc.publisher.journalExpert Review of Anti-Infective Therapyspa
dc.relation.ispartofseriesExpert Review of Anti-Infective Therapy, 1744-8336, Vol. 12, No. 10, 2014, p. 1221-1236spa
dc.relation.urihttps://www.tandfonline.com/doi/abs/10.1586/14787210.2014.956092?journalCode=ierz20
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2014
dc.rights.localAcceso abiertospa
dc.subject.keywordsAntimicrobial resistancespa
dc.subject.keywordsEnterococcusspa
dc.subject.keywordsMechanisms of resistancespa
dc.subject.keywordsVancomycin-resistant enterococcispa
dc.titleMechanisms of antibiotic resistance in enterococcispa
dc.title.translatedMechanisms of antibiotic resistance in enterococcispa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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