Oral and uro‐vaginal intra‐amniotic infection in women with preterm delivery: A case‐control study

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Fecha

2019

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Título de la revista

Publicado en

Journal of Investigative and Clinical Dentistry, 2041-1618, Vol 10, Num 2, 2019, pag e12396

Publicado por

Wiley

URI

https://hdl.handle.net/20.500.12495/2770

URL de la fuente

https://onlinelibrary.wiley.com/doi/abs/10.1111/jicd.12396

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Abstract

Aim The aim of the present study was to establish the association between the presence of oral and uro‐vaginal microorganisms in the placental membrane and preterm delivery (PTD), the premature rupture of membranes (PRM), and the clinical signs of intra‐amniotic infection. Methods Eighty‐four women with PTD and 127 women with delivery at term were assessed for the PRM, clinical signs of intra‐amniotic infection, and the presence of periodontitis. Twenty‐seven microorganisms were identified in the placental tissue using nested polymerase chain reaction (PCR). Porphyromonas gingivalis (P. gingivalis) was quantified by droplet digital PCR. Results The prevalence of microorganisms was 9.47% (20/211). P. gingivalis was the most prevalent (12/211, 5.68%). Mycoplasma hominis, Ureaplasma urealyticum, Staphylococcus spp, and Fusobacterium nucleatum were isolated at a very low frequency in the placenta. Candida albicans was associated with PTD (P = 0.027). Periodontitis was associated with clinical signs of infection (odds ratio [OR] = 3.8, 95% confidence interval [CI]: 1.28‐13.5) and with PTD (OR = 1.99; 95% CI: 1.07‐3.72). Conclusion The presence of P. gingivalis in the placenta was not associated with perinatal complications. Detecting microorganisms in the placenta by nested PCR is not relevant, as it has a poor association with clinical variables that establish the diagnosis of chorioamnionitis. However, periodontitis was associated with the clinical signs of intra‐amniotic infection and PTD.

Palabras clave

Keywords

Chorioamnionitis, Intra‐amniotic infection, Periodontitis, Porphyromonas gingivalis, Preterm delivery

Temáticas

Corioamnionitis
Periodontitis
Infecciones
Porphyromonas gingivalis

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