Dissemination of multiple drug resistance genes by class 1 integrons in klebsiella pneumoniae isolates from four countries: a comparative study

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dc.contributor.authorChowdhury, Piklu Roy
dc.contributor.authorIngold, Ana
dc.contributor.authorVanegas, Natasha
dc.contributor.authorMartínez, Elena
dc.contributor.authorMerlino, John
dc.contributor.authorMerkier, Andrea Karina
dc.contributor.authorCastro, Mercedes
dc.contributor.authorGonzález Rocha, Gerardo
dc.contributor.authorBorthagaray, Graciela
dc.contributor.authorBello Toledo, Helia
dc.contributor.authorMárquez, Carolina M.
dc.contributor.authorStokes, H. W.
dc.contributor.authorCentrón, Daniela
dc.date.accessioned2020-10-05T17:16:22Z
dc.date.available2020-10-05T17:16:22Z
dc.date.issued2011
dc.description.abstractenglishA comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://dx.doi.org/10.1128%2FAAC.01529-10
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1098-6596
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4260
dc.language.isoeng
dc.publisherAmerican Society for Microbiologyspa
dc.publisher.journalAntimicrobial Agents and Chemotherapyspa
dc.relation.ispartofseriesAntimicrobial Agents and Chemotherapy, 1098-6596, Vol. 55, No. 7, 2011 p. 3140-3149spa
dc.relation.urihttps://aac.asm.org/content/55/7/3140
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2011-07
dc.rights.localAcceso abiertospa
dc.subject.decsFarmacorresistencia bacterianaspa
dc.subject.decsKlebsiella pneumoniaespa
dc.subject.decsFactores Rspa
dc.titleDissemination of multiple drug resistance genes by class 1 integrons in klebsiella pneumoniae isolates from four countries: a comparative studyspa
dc.title.translatedDissemination of multiple drug resistance genes by class 1 integrons in klebsiella pneumoniae isolates from four countries: a comparative studyspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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