Breaking paradigms in the treatment of psoriasis: use of botulinum toxin for the treatment of plaque psoriasis

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dc.contributor.authorGonzález, César
dc.contributor.authorFranco, Manuel
dc.contributor.authorLondoño, Ángela María
dc.contributor.authorValenzuela, Fernando
dc.date.accessioned2020-11-06T14:31:15Z
dc.date.available2020-11-06T14:31:15Z
dc.date.issued2020
dc.description.abstractenglishSome studies have demonstrated that neurotransmitters are involved in the pathogenesis of numerous skin conditions, including psoriasis, addressing the close correlation between the skin and the central nervous system. There are reports showing psoriasis improvement after peripheral nervous system injury. In addition, botulinum toxin has been reported as a treatment for several diseases, including psoriasis. This is a proof‐of‐concept study of botulinum toxin and psoriasis, involving eight patients with stable and recalcitrant plaques of psoriasis vulgaris. The lesions were 5 cm2 at the maximum. Botulinum toxin Dysport (Ipsen Biopharm, Wrexham, UK), 5 units per cm2, was administered in one subcutaneous application. Patients were then evaluated at 2 and 4 weeks after treatment. Our results indicated a substantial improvement in all patients, 4 weeks after treatment, with no significant side effects. Our preliminary conclusion is that botulinum toxin represents a novel mechanism for interfering with the immunopathogenesis of psoriasis and improving the quality of life of our patients.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/dth.14319
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1529-8019
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4659
dc.language.isoeng
dc.publisherWiley-Blackwellspa
dc.publisher.journalDermatologic therapyspa
dc.relation.ispartofseriesDermatologic therapy, 1529-8019, 2020spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/dth.14319
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2020-09-19
dc.rights.localAcceso abiertospa
dc.subject.keywordsBotulinum toxinspa
dc.subject.keywordsPsoriasisspa
dc.titleBreaking paradigms in the treatment of psoriasis: use of botulinum toxin for the treatment of plaque psoriasisspa
dc.title.translatedBreaking paradigms in the treatment of psoriasis: use of botulinum toxin for the treatment of plaque psoriasisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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