EGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP)

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dc.contributor.authorCardona-Mendoza, Andrés Felipe
dc.contributor.authorRojas Puentes, Leonardo
dc.contributor.authorZatarain-Barrón, Zyanya Lucia
dc.contributor.authorFreitas, Helano C.
dc.contributor.authorGranados, Sara T.
dc.contributor.authorCastillo, Omar
dc.contributor.authorOblitas, George
dc.contributor.authorCorrales, Luis
dc.contributor.authorCastro, Christian D.
dc.contributor.authorRuiz-Patiño, Alejandro
dc.contributor.authorMartín, Claudio
dc.contributor.authorPérez, María Angelina
dc.contributor.authorGonzález, Lisde
dc.contributor.authorChirinos, Luis
dc.contributor.authorVargas Báez, Carlos Alberto
dc.contributor.authorCarranza, Hernán
dc.contributor.authorOtero, Jorge
dc.contributor.authorRodríguez Ariza, July Katherine
dc.contributor.authorRodriguez, Jenny
dc.contributor.authorArchila, Pilar
dc.contributor.authorLema, Mauricio
dc.contributor.authorAcosta Madiedo, José
dc.contributor.authorKarachaliu, Niki
dc.contributor.authorWills, Beatriz
dc.contributor.authorPino, Luis E.
dc.contributor.authorde Lima, Vladimir
dc.contributor.authorRosell, Rafael
dc.contributor.authorArrieta, Oscar
dc.contributor.orcidCardona-Mendoza, Andrés Felipe [0000-0002-6697-5471]
dc.contributor.orcidVargas Báez, Carlos Alberto [0000-0002-6076-8260]
dc.contributor.orcidRojas Puentes, Leonardo [0000-0002-7865-5424]
dc.contributor.orcidRodríguez Ariza, July Katherine [0000-0003-1168-595X]
dc.date.accessioned2020-05-18T06:37:28Z
dc.date.available2020-05-18T06:37:28Z
dc.date.issued2018
dc.description.abstractenglishObjectives Contrasting other EGFR mutations (EGFRm) in lung adenocarcinomas, insertions in exon 20 (exon20ins) are generally associated with resistance to targeted therapy, limiting therapeutic options and impoverishing the prognosis compared to other EGFRm. We sought to extensively characterize exon20ins from a large cohort of lung adenocarcinomas in Hispanic patients. Materials and methods This was a region-wide, observational longitudinal cohort study to evaluate characteristics and outcomes of patients with exon20ins in lung adenocarcinoma, based on a secondary analysis of electronic records from the Geno1.2-CLICaP Platform and extended genotype testing. Patients from six Latin-American countries were included (Argentina, Colombia, Costa Rica, Ecuador, Panama, and Mexico). Data obtained included the molecular spectrum (extended genotyping for mutations in BRAF, NRAS, PIK3CA, Her2 and MEK1, as well as for EGFR amplification, ALK and PD-L1 protein expression), clinic-pathologic characteristics, prevalence and outcomes to therapeutic approach. Results and conclusions 4.005 patients diagnosed with stage III/IV lung adenocarcinoma from 2011 to 2016 were initially screened. Among these, 88 patients had a confirmed exon20 in. and were included; median age was 66-years, 62.5% were females, 64% were never smokers and 39% presented with brain metastases. The H773insH variant was the most frequent, making up 21.6% of cases. A common EGFRm was concomitantly found in 36.4% (del19/L858R), and 8% (G719X/L861Q/S768I) of cases. Five cases had additional mutations in PI3K, KRAS and MEK1, 26% had EGFR amplification and 81.7% had PD-L1 expression 1–50%. Overall response rate to first-line therapy was 28% and overall survival was 16.4 months. Prognosis was positively influenced by the concomitant presence of common EGFRm and response to first-line. Our results suggest that patients with EGFR exon20ins have similar clinical characteristics to those with common EGFRm but a poorer prognosis. Last, the mean PD-L1 expression in this population seems higher than for patients with common EGFRm.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.lungcan.2018.10.007
dc.identifier.issn0169-5002
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2903
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalLung cancerspa
dc.relation.ispartofseriesLung cancer, 0169-5002, Vol 125, 2018, pag 265-272spa
dc.relation.urihttps://www.lungcancerjournal.info/article/S0169-5002(18)30591-9/fulltext
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsGenes erbB-1spa
dc.subject.decsGenes supresoresspa
dc.subject.decsProceso salud-enfermedadspa
dc.subject.keywordsEGFRspa
dc.subject.keywordsInsertionspa
dc.subject.keywordsMutationspa
dc.subject.keywordsSurvivalspa
dc.subject.keywordsOutcomespa
dc.subject.keywordsPD-L1spa
dc.subject.keywordsPrognosisspa
dc.titleEGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP)spa
dc.title.translatedEGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP)spa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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