An update of predictors of cerebral infarction after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis
dc.contributor.author | Florez, William A. | |
dc.contributor.author | Martinez Perez, Rafael | |
dc.contributor.author | Deora, Harsh | |
dc.contributor.author | Joaquim, Andrei F. | |
dc.contributor.author | García Ballestas, Ezequiel | |
dc.contributor.author | Quiñones Ossa, Gabriel A. | |
dc.contributor.author | Rivas Palacios, Claudio | |
dc.contributor.author | Agrawal, Amit | |
dc.contributor.author | Serrato, Sergio A. | |
dc.contributor.author | Jabbour, Pascal | |
dc.contributor.author | Moscote Salazar, Luis R. | |
dc.date.accessioned | 2023-02-20T21:35:32Z | |
dc.date.available | 2023-02-20T21:35:32Z | |
dc.date.issued | 2023 | |
dc.description.abstract | INTRODUCCIÓN: Las pruebas sobre los factores predictivos de malos resultados, como el infarto cerebral (IC), tras una hemorragia subaracnoidea por aneurisma (HSAa) no se han dilucidado por completo. ADQUISICIÓN DE EVIDENCIAS: Se realizó una revisión sistemática y un metanálisis de estudios con adultos con HSAa, teniendo en cuenta ECA y no ECA, estudios de cohortes prospectivos y retrospectivos que describen estudios clínicos, de imagen y angiográficos en pacientes con HSAa. SÍNTESIS DE LA EVIDENCIA: Tras revisar el texto completo, se consideraron elegibles 11 estudios, de los cuales se descartaron cuatro. El grado de severidad clínica fue el factor más predictivo, asociándose un mayor grado en la presentación en diferentes escalas de severidad con un aumento estadísticamente significativo del riesgo de sufrir una IC tras una HSAa (OR 2,49 [IC 95% 1,38-4,49] p=0,0003). El tamaño del aneurisma aumentó el riesgo de IC (OR 1,49 [IC 95%: 1,20-1,85] p=0,0003; I2=4%). En seis estudios analizados, se observó que un factor importante para el desarrollo posterior de IC es el vasoespasmo (OR 7,62 [2,19, 26,54], P=0,0001). CONCLUSIONES: El desarrollo de vasoespasmo es un factor de riesgo para el desarrollo de IC tras una HSAa. En nuestra revisión, tres factores se asociaron a un mayor riesgo de IC: la gravedad clínica en el momento de la presentación, el vasoespasmo y el tamaño del aneurisma. La principal limitación de este metanálisis es que los estudios incluidos se realizaron de forma retrospectiva o fueron análisis post hoc de un ensayo prospectivo. | spa |
dc.description.abstractenglish | INTRODUCTION: Evidence about predictors of poor outcomes such as cerebral infarction (CI) after aneurysmal subarachnoid hemorrhage (aSAH) has not been fully elucidated. EVIDENCE ACQUISITION: We performed a systematic review and meta-analysis on studies with adults with aSAH considering RCT and non-RCT, prospective, and retrospective cohort studies describing clinical, imaging as well as angiographic studies in patients with aSAH. EVIDENCE SYNTHESIS: After reviewing the complete text, 11 studies were considered eligible, out of which four were ruled out. Degree of clinical severity was the most predictive factor with a higher degree at the presentation on different severity scales being associated with a statistically significant increasing the risk of suffering a CI following aSAH (OR 2.49 [95% CI 1.38-4.49] P=0.0003). Aneurysm size increased the risk of CI (OR 1.49 [95% CI 1.20-1.85] P=0.0003; I2=4%). In six studies analyzed, it was found that an important factor for the subsequent development of CI is vasospasm (OR 7.62 [2.19, 26.54], P=0.0001). CONCLUSIONS: The development of vasospasm is a risk factor for CI development after aSAH. In our review, three factors were associated with an increased risk of CI: clinical severity at presentation, vasospasm, and aneurysm size. The major limitation of this meta-analysis is that included studies were conducted retrospectively or were post hoc analyses of a prospective trial. | eng |
dc.format.mimetype | application/pdf | |
dc.identifier.doi | https://doi.org/10.23736/S0390-5616.22.05445-5 | |
dc.identifier.instname | instname:Universidad El Bosque | spa |
dc.identifier.issn | 1827-1855 | |
dc.identifier.reponame | reponame:Repositorio Institucional Universidad El Bosque | spa |
dc.identifier.repourl | repourl:https://repositorio.unbosque.edu.co | |
dc.identifier.uri | https://hdl.handle.net/20.500.12495/10008 | |
dc.language.iso | eng | |
dc.publisher | Edizioni Minerva Medica | spa |
dc.publisher.journal | Journal of Neurosurgical Sciences | spa |
dc.relation.ispartofseries | Journal of Neurosurgical Sciences, 1827-1855, 67, 1, February 2023, 1 - 91 | spa |
dc.relation.uri | https://www.minervamedica.it/en/journals/neurosurgical-sciences/article.php?cod=R38Y2023N01A0001 | |
dc.rights.accessrights | https://purl.org/coar/access_right/c_14cb | |
dc.rights.accessrights | info:eu-repo/semantics/closedAccess | |
dc.rights.accessrights | Acceso cerrado | |
dc.title | An update of predictors of cerebral infarction after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis | spa |
dc.title.translated | Una actualización de los predictores de infarto cerebral tras hemorragia subaracnoidea por aneurisma: revisión sistemática y metaanálisis | spa |
dc.type.coar | https://purl.org/coar/resource_type/c_6501 | |
dc.type.coarversion | https://purl.org/coar/version/c_970fb48d4fbd8a85 | |
dc.type.driver | info:eu-repo/semantics/article | |
dc.type.hasversion | info:eu-repo/semantics/publishedVersion | |
dc.type.local | Artículo de revista |
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