Effect of bisphosphonates on orthodontic tooth movement in osteoporotic patients: A review




Título de la revista

Publicado en

Journal of the World Federation of Orthodontists, 2212-4438, Vol 7, Num 2, 2018, pag 49-55

Publicado por


ISSN de la revista

Título del volumen




Background This review discusses the side effects of bisphosphonates (BPs) in orthodontic tooth movement (OTM) with the main focus on suggesting key aspects for the clinical management of patients with osteoporosis by orthodontists. Methods Studies were selected through a search of the PubMed electronic database. The keywords used for the search were BPs, tooth movement, orthodontics, osteoporosis, and bone remodeling. The search was restricted to English-language articles published between 2001 and 2017. Results This article provides updated information about the mechanism of action of BPs; their effects on bone metabolism, particularly with regard to OTM; oral radiographic considerations in the osteoporotic patient; and the potential use of bone turnover biomarkers from oral fluid as predictors of bone remodeling and key aspects for the clinical management of patients with osteoporosis by orthodontists and dentists. Conclusions The interactions of BPs and oral/maxillofacial tissues with a high bone turnover rate such as maxilla or jaws can influence the success rate of dental procedures that involve bones around the teeth, such as extractions, periodontal surgery, and OTM.

Palabras clave


Bisphosphonates, Bone remodeling, Orthodontics, Osteoporosis, Tooth movement


Compuestos organofosforados
Remodelación ósea
Fenómenos fisiológicos de la dentición