Autoantibodies and fecal calprotectin levels in a group of Colombian patients with inflammatory bowel disease

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dc.contributor.authorGarcía, Ferney
dc.contributor.authorMartínez, Carlos
dc.contributor.authorJuliao, Haroldo
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorValle-Oñate, Rafael Raúl
dc.contributor.authorRueda, Juan C.
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-07-10T15:57:34Z
dc.date.available2020-07-10T15:57:34Z
dc.description.abstractenglishBackground: The purpose of the study is to investigate the frequency of serum anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-nuclear antibodies (ANAS), IgA, C reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fecal calprotectin (FC) and its association between diagnosis, endoscopic findings, histopathologic and clinical activity, in patients with diagnosis or suspected inflammatory bowel disease (IBD). Methods: An observational cross-section study was designed including 52 patients with IBD or suspected IBD. ASCA, ANCA, ANAS, IgA, CRP, ESR and FC were measured. Patients were divided according to histological findings into ulcerative colitis (UC), Crohn's disease (CD) and others (normal mucosa, chronic proctocolitis, nonspecific colitis and ileitis). A descriptive analysis was made and associations were evaluated using chi2 test, Kruskal Wallis and Mann- Whitney U test. Results: The association between IBD and ASCA levels was statistically significant (p=0.036). ANCA levels showed statistical significance in IBD patients (p=0.048). When comparing FC levels within UC, CD and others a statistical significance was obtained (p=0.032). A large percentage of patients (78.5%) with high positive levels FC were classified as active histopathology. A significant percentage (54.5%) with levels up to 50 mg/kg had quiescent activity. Positive levels of FC were related with serum activity markers with statistical significance (CRP: p=0.007 and ESR: p=0.003). Conclusions: The frequencies of p-ANCA and ASCAs for UC and CD were established in a Colombian population. IBD patients with histopathologic activity had higher levels of FC. We also found that patients with quiescent disease have elevated FC levels.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.23736/S0393-3660.16.03318-0
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0393-3660
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3417
dc.language.isoeng
dc.publisherEdizioni Minerva Medicaspa
dc.publisher.journalGazzetta medica italiana archivio per le scienze medichespa
dc.relation.ispartofseriesGazzetta medica italiana archivio per le scienze mediche, 0393-3660, Vol. 176, Nro. 3, 2017, p. 132-141spa
dc.relation.urihttps://www.minervamedica.it/en/journals/gazzetta-medica-italiana/article.php?cod=R22Y2017N03A0132
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-03
dc.rights.localAcceso abiertospa
dc.subject.decsAutoanticuerposspa
dc.subject.decsBiomarcadoresspa
dc.subject.decsEstudios transversalesspa
dc.subject.keywordsInflammatory bowel diseasespa
dc.subject.keywordsCrohn diseasespa
dc.subject.keywordsColitis, ulcerativespa
dc.titleAutoantibodies and fecal calprotectin levels in a group of Colombian patients with inflammatory bowel diseasespa
dc.title.translatedAutoantibodies and fecal calprotectin levels in a group of Colombian patients with inflammatory bowel diseasespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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