A theoretical model of dentinogenesis: dentin and dentinal tubule formation

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dc.contributor.authorNiño-Barrera, Javier L
dc.contributor.authorGutiérrez, María L
dc.contributor.authorGarzón-Alvarado, Diego A
dc.date.accessioned2020-07-17T17:56:00Z
dc.date.available2020-07-17T17:56:00Z
dc.date.issued2013
dc.description.abstractenglishDentinogenesis, odontoblast dentin formation, includes dentinal growth, mineralization and dentinal tubule formation. Odontoblasts synthesize collagen resulting in collagen apposition contributing to dentinogenesis. Furthermore, within the tubule, they express non-collagenous proteins, such as dentin phosphoprotein (DPP), associated with hydroxyapatite crystal formation and growth. The aim of this work was to determine patterns of growth and dentin formation and quantification of its mineralization. Findings from our work are relevant to endodontics for future regenerative treatment. We formulated a 3D domain mathematical model, which recreates the events that lead to dentinal tubule mineralization. As reference we used collagen apposition and DPP activity. We obtained a model depicting predentin's mineralization distribution during dentin development. Furthermore, we verified different DPP diffusion coefficients to test the model's sensitivity. We present a model to shed light on the process of dentin and dentinal tubule formation, and its relation to diffusion and mineralization processes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cmpb.2013.06.010
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1872-7565
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3556
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalComputer Methods and Programs in Biomedicinespa
dc.relation.ispartofseriesComputer Methods and Programs in Biomedicine, 1872-7565, Vol. 112, No. 1, 2013 p. 219-227spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S016926071300196X?via%3Dihub
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2013-10
dc.rights.localAcceso abiertospa
dc.subject.keywordsDentinspa
dc.subject.keywordsDentinal tubulesspa
dc.subject.keywordsFinite elementsspa
dc.subject.keywordsMathematical modelingspa
dc.titleA theoretical model of dentinogenesis: dentin and dentinal tubule formationspa
dc.title.translatedA theoretical model of dentinogenesis: dentin and dentinal tubule formationspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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