Seronegative paraneoplastic limbic encephalitis associated with thymoma

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dc.contributor.authorToro, Jaime
dc.contributor.authorCuellar-Giraldo, David
dc.contributor.authorDuque, Alejandra
dc.contributor.authorMinota, Karla
dc.contributor.authorPatiño, Jorge E.
dc.contributor.authorGarciá, Manuel
dc.contributor.orcidToro, Jaime [0000-0001-7129-0058]
dc.date.accessioned2020-07-09T19:48:12Z
dc.date.available2020-07-09T19:48:12Z
dc.description.abstractenglishParaneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, advances in the field now permit the diagnosis without autoantibody test results. In this case illustrating the new diagnostic criteria, we report a 70-year-old woman who was brought to the emergency room after the acute onset of cognitive impairment, altered mental status, and choreoathetoid movements. Brain magnetic resonance imaging showed hyperintense signals in both temporal lobes, and a chest computed tomogram revealed a thymoma. Because the patient met current diagnostic criteria for autoimmune limbic encephalitis, we were able to start treatment before her antibody tests were processed. The patient received immunotherapy and her tumor was resected. Her choreoathetoid movements disappeared and her other neurologic symptoms improved. Her cerebrospinal fluid proved to be negative for paraneoplastic limbic encephalitis antibodies. Most but not all patients with paraneoplastic limbic encephalitis associated with thymoma have evidence of paraneoplastic antibodies. Prompt management of the underlying malignancy determines whether patients survive and may minimize future cognitive and functional impairment. Practicing neurologists and psychiatrists should be aware of this diagnosis.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/wnn.0000000000000134
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1543-3641
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3391
dc.language.isoeng
dc.publisherWolters Kluwer Healthspa
dc.publisher.journalCognitive and behavioral neurologyspa
dc.relation.ispartofseriesCognitive and behavioral neurology, 1543-3641. Vol. 30, Nro. 3, 2017, p.125-128spa
dc.relation.urihttps://journals.lww.com/cogbehavneurol/Fulltext/2017/09000/Seronegative_Paraneoplastic_Limbic_Encephalitis.6.aspx
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017-09
dc.rights.localAcceso abiertospa
dc.subject.decsLíquido cefalorraquídeospa
dc.subject.decsEncefalitis límbicaspa
dc.subject.decsEspectroscopía de resonancia magnéticaspa
dc.subject.keywordsParaneoplastic limbic encephalitisspa
dc.subject.keywordsSeronegativespa
dc.subject.keywordsThymomaspa
dc.titleSeronegative paraneoplastic limbic encephalitis associated with thymomaspa
dc.title.translatedSeronegative paraneoplastic limbic encephalitis associated with thymomaspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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