Diagnostic accuracy of clinical visualization and light-based tests in precancerous and cancerous lesions of the oral cavity and oropharynx: a systematic review and meta-analysis

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dc.contributor.authorBuenahora, María Rosa
dc.contributor.authorPeraza L., Alberto
dc.contributor.authorDíaz Báez, David
dc.contributor.authorBustillo, Jairo
dc.contributor.authorSantacruz, Iván
dc.contributor.authorGoretty Trujillo, Tamy
dc.contributor.authorLafaurie, Gloria Inés
dc.contributor.authorChambrone, Leandro
dc.date.accessioned2021-02-26T15:32:00Z
dc.date.available2021-02-26T15:32:00Z
dc.description.abstractenglishObjective Evaluate and compare the performance of autofluorescence, chemiluminescence, and clinical visual examination in the detection of oral potentially malignant disorders (OPMD), oral cancer (OC), and oropharyngeal cancer (OPC). Materials and methods A systematic review with meta-analysis based on diagnostic test studies. A literature search was carried out in the MEDLINE and EMBASE databases through August 30, 2020. For this review, the quality assessment tool of diagnostic precision studies (QUADAS-2) was used. Hierarchical regression models were used to estimate pooled diagnostic precision values in a random effects model. Results A total of 40 studies were identified for this review according to each test evaluated: 5.562 samples for autofluorescence, 1.353 samples for chemiluminescence, and 1.892 samples for clinical examination. The summary measures sensitivity and specificity of the clinical examinationwere 63%and 78%, respectively, AUC = 0.78 95%CI (0.74–0.81). In the autofluorescence test, these were 86%and 72%, respectively,AUC = 0.86 95%CI (0.83–0.89); and the chemiluminescent test were 67%and 48%, respectively, AUC = 0.59 95% CI (0.54–0.63) Conclusions Autofluorescence devices displayed superior accuracy levels in the identification of premalignant lesions and early neoplastic changes compared to clinical examination and chemiluminescent test. Overall, biopsy remains the gold standard for the definitive diagnosis of OPMD, OC, and OPC. Clinical Relevance Light-based clinical methods such as autofluorescence and chemiluminescence techniques have been used in clinical diagnosis for the differentiation of OPMD and malignant and benign lesions; although detailed visual examination appears to be effective in identifying, previous systematic reviews have not evaluated a relevant number of studies and they did not evaluate the accuracy of the clinical examination.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00784-020-03746-y
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1436-3771
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/5457
dc.language.isoeng
dc.publisherSpringer Nature Switzerland AG.spa
dc.publisher.journalClinical Oral Investigationsspa
dc.relation.ispartofseriesClinical Oral Investigations, 1436-3771, 2021, p. 1-15spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00784-020-03746-y
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2021
dc.rights.localAcceso abiertospa
dc.subject.keywordsMouth neoplasmsspa
dc.subject.keywordsSensitivity and specificityspa
dc.subject.keywordsPredictive value of testsspa
dc.subject.keywordsDiagnostic testspa
dc.titleDiagnostic accuracy of clinical visualization and light-based tests in precancerous and cancerous lesions of the oral cavity and oropharynx: a systematic review and meta-analysisspa
dc.title.translatedDiagnostic accuracy of clinical visualization and light-based tests in precancerous and cancerous lesions of the oral cavity and oropharynx: a systematic review and meta-analysisspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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