In vivo differential susceptibility of sensory neurons to rabies virus infection

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dc.contributor.authorVelandia-Romero, Myriam Lucía
dc.contributor.authorCastellanos, Jaime
dc.contributor.authorMartínez-Gutiérrez, Marlén
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.contributor.orcidVelandia-Romero, Myriam Lucía [0000-0002-3340-7304]
dc.date.accessioned2020-10-28T22:00:19Z
dc.date.available2020-10-28T22:00:19Z
dc.date.issued2013
dc.description.abstractenglishThere is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory neurons capture and transport the virus to the spinal cord (SC) and then to the brain. It is probable that preferences for one pathway or another depend on the site of inoculation and the post-infection time. Therefore, in the present study, we evaluated different vertebral segments and post-infection times, along with the location, number, and subpopulation of sensory neurons susceptible to infection after inoculating RABV in the footpads of adult mice. It was noted that the virus inoculated in the footpad preferentially entered the CNS through the large-sized DRG sensory neurons, while infection of the motor neurons occurred later. Further, it was found that the virus was dispersed in spinal cord trans-synaptically through the interneurons, arriving at both sensory neurons and contralateral motor neurons. In conclusion, we observed that RABV inoculated in the plantar footpad is captured preferentially by large sensory neurons and is transported to the DRG, where it replicates and is spread to the SC using transynaptic jumps, infecting sensory and motor neurons at the same level before ascending to the brain.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s13365-013-0179-5
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1355-0284
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4597
dc.language.isoeng
dc.publisherSpringerspa
dc.publisher.journalJournal of NeuroVirologyspa
dc.relation.ispartofseriesJournal of NeuroVirology, 1355-0284, Vol. 19, 2013, p. 367–375spa
dc.relation.urihttps://link-springer-com.ezproxy.unbosque.edu.co/article/10.1007/s13365-013-0179-5
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2013-08-20
dc.rights.localAcceso abiertospa
dc.subject.keywordsRabies virusspa
dc.subject.keywordsSensory neuronsspa
dc.subject.keywordsMotors neuronsspa
dc.subject.keywordsTransynaptic infectionspa
dc.titleIn vivo differential susceptibility of sensory neurons to rabies virus infectionspa
dc.title.translatedIn vivo differential susceptibility of sensory neurons to rabies virus infectionspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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