Higher PAPP-A Values in Pregnant Women Complicated with Preeclampsia Than with Gestational Hypertension

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dc.contributor.authorMontserrat, Uriel
dc.contributor.authorRomero Infante, Ximena Carolina
dc.contributor.authorRincón Franco, Sara
dc.contributor.authorIbáñez Pinilla, Edgar Antonio
dc.contributor.authorRojas, Nydia Alexandra
dc.contributor.orcidMontserrat, Uriel [0000-0001-5987-8633]
dc.contributor.orcidRomero Infante, Ximena Carolina [0000-0002-7040-2705]
dc.contributor.orcidRincón Franco, Sara [0000-0002-4594-9151]
dc.contributor.orcidIbáñez Pinilla, Edgar Antonio [0000-0002-9527-9248]
dc.contributor.orcidRojas, Nydia Alexandra [0000-0002-3688-0375]
dc.date.accessioned2023-06-07T20:29:13Z
dc.date.available2023-06-07T20:29:13Z
dc.date.issued2023
dc.description.abstractenglishThe purpose of this study is to compare the levels of maternal serum pregnancy–associated plasma protein-A at the first trimester in pregnancies complicated by impaired placental diseases, such as preeclampsia (PE), intrauterine fetal growth restriction (IUGR), and gestational hypertension (GH), with those in pregnancies without the development of any of these outcomes to expand the knowledge of how this protein behaves in the different impaired placental diseases. This current work is an observational study based on a prospective cohort. Pregnancy-associated plasma protein-A was measured in 422 patients who had completed maternal-perinatal outcomes. Comparisons of pregnancy characteristics and the biomarker between outcome groups (PE, IUGR, gestational hypertension, and not impaired placental outcomes) were analyzed. PAPP-A MoM in the IUGR (0.8 IQR: 0.6–0.9) and GH groups (0.5 IQR: 0.3–1.4) compared to the PE group (1.06 IQR: 0.66–1.52) was significantly lower (p < 0.005). Pregnant women who developed early-onset PE (1.11 IQR 1.08–1.18) presented significant differences with the IUGR group (0.83 IQR: 0.59–0.98; p = 0.002) and those who developed preterm-PE (1.19 IQR: 0.66–1.58; p = 0.045). The results demonstrate that the levels of PAPP-A at first trimester in the sample of women who developed PE, and specially term-PE, were higher than those in women who developed GH or IUGR. The GH group had the lowest PAPP-A values in this sample of pregnant women. Research in a population with a high prevalence of preeclampsia is still lacking and deserves more extended studies to define if these patients could have different rates of PAPP-A.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s43032-023-01176-1
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1933-7205
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/10748
dc.language.isoeng
dc.publisherSpringer Naturespa
dc.publisher.journalReproductive Sciencesspa
dc.relation.ispartofseriesReproductive Sciences, 1933-7205, 14, 2023, 1-9spa
dc.relation.urihttps://link.springer.com/article/10.1007/s43032-023-01176-1
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.keywordsPregnancy-associated Plasma Protein-A (PAPP-a)spa
dc.subject.keywordsPreeclampsiaspa
dc.subject.keywordsIUGRspa
dc.subject.keywordsGestational Hypertensionspa
dc.subject.keywordsHypertensive Disorders of Pregnancyspa
dc.titleHigher PAPP-A Values in Pregnant Women Complicated with Preeclampsia Than with Gestational Hypertensionspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttps://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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