Efficacy of local antimicrobials in the non‐surgical treatment of patients with periodontitis and diabetes: A systematic review

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dc.contributor.authorRovai, Emanuel S.
dc.contributor.authorSouto, Maria Luisa S.
dc.contributor.authorGanhito, Juliana A.
dc.contributor.authorHolzhausen, Marinella
dc.contributor.authorChambrone, Leandro
dc.contributor.authorPannuti, Claudio M.
dc.contributor.orcidChambrone, Leandro [0000-0002-2838-1015]
dc.date.accessioned2020-07-30T15:27:47Z
dc.date.available2020-07-30T15:27:47Z
dc.date.issued2020
dc.description.abstractenglishBackground: Patients with diabetes present a worse response to periodontal treatment. Local antimicrobials as an adjunct to scaling and root planing (SRP) provide additional benefits in the treatment of periodontitis in healthy patients. This review aims to evaluate the effects of local antimicrobials as an adjunct to SRP, compared with SRP alone, on periodontal clinical parameters of patients with chronic periodontitis (CP) and diabetes mellitus (DM). Methods: Only randomized controlled trials with: 1) at least 6 months of follow‐up; 2) SRP, in combination with local antimicrobials; and 3) patients with periodontitis and DM were considered eligible. MEDLINE, EMBASE, and LILACS databases were searched for articles published up to January 2016. Random‐effects meta‐analyses were conducted for clinical attachment level (CAL), probing depth (PD), bleeding on probing, and gingival index change after treatment. Results: Of 153 papers potentially relevant to this review, six were included. The majority of trials showed a significant PD reduction and CAL gain associated with use of local antimicrobials in patients with type 1 and type 2 DM. Only studies that included well‐controlled patients and applied antimicrobials at the deepest sites or sites with baseline PD ≥5 mm presented significant PD reduction and CAL gain. Conclusion: In patients with DM and CP, use of local antimicrobials as an adjunct to SRP may result in additional benefits compared with SRP alone in PD reduction and CAL gain, especially in well‐controlled individuals and deep sites.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi-org.ezproxy.unbosque.edu.co/10.1902/jop.2016.160214
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn0022-3492
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/3616
dc.language.isoeng
dc.publisherWileyspa
dc.publisher.journalJournal of Periodontologyspa
dc.relation.ispartofseriesJournal of Periodontology, 0022-3492, Vol 87, Nro 12, 2016, p. 1406-1417spa
dc.relation.urihttps://aap-onlinelibrary-wiley-com.ezproxy.unbosque.edu.co/doi/full/10.1902/jop.2016.160214
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2016-12-01
dc.rights.localAcceso abiertospa
dc.subject.keywordsAnti‐infective agentsspa
dc.subject.keywordsDiabetes mellitusspa
dc.subject.keywordsPeriodontal diseasesspa
dc.subject.keywordsReview, systematicspa
dc.subject.keywordsRoot planingspa
dc.titleEfficacy of local antimicrobials in the non‐surgical treatment of patients with periodontitis and diabetes: A systematic reviewspa
dc.title.translatedEfficacy of local antimicrobials in the non‐surgical treatment of patients with periodontitis and diabetes: A systematic reviewspa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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