Humanized mice in dengue research: a comparison with other mouse models

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dc.contributor.authorCorolnel-Ruíz, Carolina
dc.contributor.authorGutiérrez Barbosa, Hector Hernando
dc.contributor.authorMedina-Moreno, Sandra M.
dc.contributor.authorVelandia-Romero, Myriam Lucía
dc.contributor.authorChua, Joel
dc.contributor.authorCastellanos, Jaime
dc.contributor.authorZapata, Juan
dc.contributor.orcidCastellanos, Jaime [0000-0003-1596-8383]
dc.contributor.orcidVelandia-Romero, Myriam Lucía [0000-0002-3340-7304]
dc.contributor.orcidCoronel-Ruiz, Carolina [0000-0003-2202-5682]
dc.contributor.orcidCorolnel-Ruíz, Carolina [0000-0003-2202-5682]
dc.contributor.orcidGutiérrez Barbosa, Hector Hernando [0000-0003-2767-6134]
dc.contributor.orcidCorolnel-Ruíz, Carolina [0000-0003-2202-5682]
dc.contributor.orcidGutiérrez Barbosa, Hector Hernando [0000-0003-2767-6134]
dc.date.accessioned2020-03-07T15:02:10Z
dc.date.available2020-03-07T15:02:10Z
dc.date.issued2020
dc.description.abstractenglishAbstract: Dengue virus (DENV) is an arbovirus of the Flaviviridae family and is an enveloped virion containing a positive sense single-stranded RNA genome. DENV causes dengue fever (DF) which is characterized by an undifferentiated syndrome accompanied by fever, fatigue, dizziness, muscle aches, and in severe cases, patients can deteriorate and develop life-threatening vascular leakage, bleeding, and multi-organ failure. DF is the most prevalent mosquito-borne disease affecting more than 390 million people per year with a mortality rate close to 1% in the general population but especially high among children. There is no specific treatment and there is only one licensed vaccine with restricted application. Clinical and experimental evidence advocate the role of the humoral and T-cell responses in protection against DF, as well as a role in the disease pathogenesis. A lot of pro-inflammatory factors induced during the infectious process are involved in increased severity in dengue disease. The advances in DF research have been hampered by the lack of an animal model that recreates all the characteristics of this disease. Experiments in nonhuman primates (NHP) had failed to reproduce all clinical signs of DF disease and during the past decade, humanized mouse models have demonstrated several benefits in the study of viral diseases affecting humans. In DENV studies, some of these models recapitulate specific signs of disease that are useful to test drugs or vaccine candidates. However, there is still a need for a more complete model mimicking the full spectrum of DENV. This review focuses on describing the advances in this area of research.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/vaccines8010039
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn2076-393X
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2010
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institutespa
dc.publisher.journalVaccinesspa
dc.relation.ispartofseriesVaccines, 2076-393X, Vol. 8, Nro. 1, 2020spa
dc.relation.urihttps://www.mdpi.com/2076-393X/8/1/39/htm
dc.rightsAttribution 4.0 International*
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf101
dc.rights.creativecommons2020
dc.rights.localAcceso abiertospa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.decsInmunidad activaspa
dc.subject.decsPatogénesis homeopáticaspa
dc.subject.decsVacunasspa
dc.subject.keywordsDengue mouse modelsspa
dc.subject.keywordsDENVspa
dc.subject.keywordsDrug developmentspa
dc.titleHumanized mice in dengue research: a comparison with other mouse modelsspa
dc.title.translatedHumanized mice in dengue research: a comparison with other mouse models
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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