Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?

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dc.contributor.authorUnriza-Puin, Sonia
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorLafaurie, Gloria Ines
dc.contributor.authorValle-Oñate, Rafael
dc.contributor.authorChalem, Philippe
dc.contributor.authorChila, Lorena
dc.contributor.authorBello-Gualtero, Juan Manuel
dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.orcidLafaurie, Gloria Ines [0000-0003-3986-0625]
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-11-04T20:45:19Z
dc.date.available2020-11-04T20:45:19Z
dc.date.issued2020
dc.description.abstractenglishThe aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P. gingivalis antibodies was evaluated. Groupwise comparisons were analysed using the McNemar and Wilcoxon tests. A conditional logistic regression analysis was performed to establish the associations between BMI, ACPAs and periodontitis in both groups. In the FDR group, 70% of the subjects were female, with a mean age of 37.3 ± 13 years. Obesity was observed in 17 and 7% of the FDRs and controls, respectively. ACPAs were found in 7% of the FDRs vs. 2.5% of the controls. Periodontitis was diagnosed in 79 and 56% of the FDRs and controls, respectively. Among the FDRs, 15% had severe periodontitis. There were associations in the FDR group related to the presence of obesity (OR 2.93, 95% CI 1.03–8.28), ACPAs (OR 2.45, 95% CI 0.7–8.32) and periodontitis (OR 3.70 95% CI 1.89–7.29). Regarding anti-P. gingivalis antibodies and smoking history, no differences were found between the groups. Obesity, ACPAs and periodontitis (diagnosis and severity) can be considered as relevant conditions associated with the development of RA in FDRs.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s10067-016-3519-z
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1434-9949
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlrepourl:https://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/4628
dc.language.isoeng
dc.publisher.journalClinical Rheumatologyspa
dc.relation.ispartofseriesClinical Rheumatology, 1434-9949, Vol. 36, No. 4, 2017, p. 799-806spa
dc.relation.urihttps://link.springer.com/article/10.1007/s10067-016-3519-z
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2017
dc.rights.localAcceso abiertospa
dc.subject.keywordsAnti-citrullinated protein antibodiesspa
dc.subject.keywordsAutoantibodiesspa
dc.subject.keywordsObesityspa
dc.subject.keywordsPeriodontitisspa
dc.subject.keywordsRheumatoid arthritisspa
dc.titleAre obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?spa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículo de revista

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