Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions

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Munita_Jose_M_2014.pdf (280.71 KB)

Fecha

2014

Autores

Título de la revista

Publicado en

Clinical Infectious Diseases, 1058-4838, Vol. 59, Nro. 9, 2014, p. 1277–1280

Publicado por

Oxford University Press

URI

https://hdl.handle.net/20.500.12495/3347

URL de la fuente

https://academic.oup.com/cid/article/59/9/1277/424852

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Descripción

Abstract

High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations >2 μg/mL.

Palabras clave

Keywords

Daptomycin, Enterococcus faecium, Resistance, Treatment failure

Temáticas

Daptomicina
Enterococcus faecium
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