Juvenile polyautoimmunity in a rheumatology setting

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dc.contributor.authorMalagón, Clara
dc.contributor.authorGomez, Maria del Pilar
dc.contributor.authorMosquera, Catalina
dc.contributor.authorVargas, Camilo
dc.contributor.authorGonzalez, Tatiana
dc.contributor.authorArango, Cristine
dc.contributor.authorMartin, Lorena
dc.contributor.authorPerez, Pilar
dc.contributor.authorAmaya-Uribe, Laura
dc.contributor.authorMolano-Gonzalez, Nicolas
dc.contributor.authorAnaya, Juan-Manuel
dc.date.accessioned2020-05-13T20:12:01Z
dc.date.available2020-05-13T20:12:01Z
dc.date.issued2019
dc.description.abstractenglishOvert polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44%) patients. Multiple autoimmune syndrome was observed in 62 (19.8%) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8%), juvenile idiopathic arthritis (JIA, n = 40, 12.7%), Hashimoto's thyroiditis (HT, n = 24, 7.66%), immune thrombocytopenic purpura (ITP n = 20, 6.39%), antiphospholipid syndrome (APS, n = 15, 4.79%), and vitiligo (VIT, n = 15, 4.79%) were the most frequent and represented 79.23% of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (λr = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sjögren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2018.11.006
dc.identifier.issn1568-9972
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2711
dc.language.isoeng
dc.publisherElsevierspa
dc.publisher.journalAutoimmunity Reviewsspa
dc.relation.ispartofseriesAutoimmunity Reviews, 1568-9972, Vol 18, Num 4, 2019, pag 369-381spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S1568997219300412?via%3Dihub#!
dc.rights.creativecommons2019
dc.rights.localAcceso cerradospa
dc.subject.decsSíndrome de inmunodeficiencia adquiridaspa
dc.subject.decsEnfermedades reumáticasspa
dc.subject.decsArtritisspa
dc.subject.keywordsAutoimmune diseasesspa
dc.subject.keywordsPolyautoimmunityspa
dc.subject.keywordsJuvenile patientsspa
dc.subject.keywordsAutoimmune tautologyspa
dc.subject.keywordsSystemic lupus erythematousspa
dc.subject.keywordsJuvenile idiopathic arthritisspa
dc.titleJuvenile polyautoimmunity in a rheumatology settingspa
dc.title.translatedJuvenile polyautoimmunity in a rheumatology settingspa
dc.typearticlespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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