The frequency of HLA-B27 in a colombian population with signs of spondyloarthritis

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dc.contributor.authorRomero-Sánchez, Consuelo
dc.contributor.authorChila-Moreno, Lorena
dc.contributor.authorGómez, Alberto
dc.contributor.authorCasas G, Maria Consuelo
dc.contributor.authorBautista-Molano, Wilson Armando
dc.contributor.authorBriceño, Ignacio
dc.contributor.authorRueda, Juan C.
dc.contributor.authorDe Avila, Juliette
dc.contributor.authorLondono, John
dc.contributor.authorValle-Onate., Rafael
dc.contributor.orcidRomero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.contributor.orcidBautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.date.accessioned2020-05-18T10:48:29Z
dc.date.available2020-05-18T10:48:29Z
dc.date.issued2018
dc.description.abstractenglishBackground: The strong association between HLA-B27 and spondyloarthritis (SpA) has demonstrated that typing the HLA-B27 antigen is a crucial step in diagnosis and aids in defining the progression and severity of disease. Objective: To describe the frequency of HLA-B27 in Colombian individuals with clinical manifestations associated with SpA. Materials and Methodology: We retrospectively analyzed 4109 HLA-B27 typing requests to the Hospital Militar Central and the Instituto de Referencia Andino from Colombian individuals with clinical signs suggestive of SpA between 2009 and 2012. We used basic digital cytometry followed by Polymerase Chain Reaction with sequence specific primers when confirmation was needed. We determined the frequency of HLA-B27 in the population and levels of association of HLA-B27 with SpA. Results: Our population included 1585 men (36.8%) and 2524 women (61.4%). The predominant age range was between 19 and 45 years (49.9%). The majority (95.4%) of the study population came from the Andean region and eastern plains. The most frequent clinical manifestations were peripheral. Only a small fraction (12.1%) of the 4109 subjects was HLA-B27 positive. Of those, 56.9% were male, and 54.7% were between 19 and 45 years old. In contrast, when rheumatologists referred the HLA B27, 64% were found to be positive. Conclusion: The frequency of the HLA-B27 allele in individuals with clinical signs suggestive of SpA was low, in accordance with the lower prevalence found in Colombian patients diagnosed with SpA compared to American and European population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1573397113666170329121552
dc.identifier.instnameinstname:Universidad El Bosquespa
dc.identifier.issn1875-6360
dc.identifier.reponamereponame:Repositorio Institucional Universidad El Bosquespa
dc.identifier.repourlhttps://repositorio.unbosque.edu.co
dc.identifier.urihttps://hdl.handle.net/20.500.12495/2940
dc.language.isoeng
dc.publisherBentham Science Publishersspa
dc.publisher.journalCurrent Rheumatology Reviewsspa
dc.relation.ispartofseriesCurrent Rheumatology Reviews, 1875-6360, Vol 14, Num 3, 2018, pag 246 - 250spa
dc.relation.urihttps://www.eurekaselect.com/151184/article
dc.rights.accessrightshttps://purl.org/coar/access_right/c_abf2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.accessrightsAcceso abierto
dc.rights.creativecommons2018
dc.rights.localAcceso cerradospa
dc.subject.decsCitometría de flujospa
dc.subject.decsTécnicas citológicasspa
dc.subject.decsAntígenos HLA-Bspa
dc.subject.keywordsFlow cytometryspa
dc.subject.keywordsHLA-B27spa
dc.subject.keywordsPolymerase chain reactionspa
dc.subject.keywordsAnkylosing spondylitisspa
dc.subject.keywordsAutoimmune diseasesspa
dc.subject.keywordsPopulationspa
dc.titleThe frequency of HLA-B27 in a colombian population with signs of spondyloarthritisspa
dc.title.translatedThe frequency of HLA-B27 in a colombian population with signs of spondyloarthritisspa
dc.typearticlespa
dc.type.coarhttps://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localartículospa

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